Readings

Week # topics READINGS
1

Introduction to Biomaterials

See the Lecture Summary

[No Readings]
2

Vaccine Delivery from Biodegradable Microspheres

See the Lecture Summary

Feng L, Qi XR, Zhou XJ, Maitani Y, Wang SC, Jiang Y, Nagai T. Pharmaceutical and immunological evaluation of a single-dose hepatitis B vaccine using PLGA microspheres. J Control Release 2006;112:35-42.
doi: 10.1016/j.jconrel.2006.01.012

Jaganathan KS, Rao YU, Singh P, Prabakaran D, Gupta S, Jain A, Vyas SP. Development of a single dose tetanus toxoid formulation based on polymeric microspheres: a comparative study of poly(d,l-lactic-co-glycolic acid) versus chitosan microspheres. Int J Pharm 2005;294:23-32.
doi: 10.1016/j.ijpharm.2004.12.026

3

Advanced Techniques for Improving Vaccine Efficacy

See the Lecture Summary

Sullivan SP, Koutsonanos DG, Del Pilar Martin M, Lee JW, Zarnitsyn V, Choi SO, Murthy N, Compans RW, Skountzou I, Prausnitz MR. Dissolving polymer microneedle patches for influenza vaccination. Nat Med 2010;16:915-20.
doi: 10.1038/nm.2182

Chahal JS, Khan OF, Cooper CL, McPartlan JS, Tsosie JK, Tilley LD, Sidik SM, Lourido S, Langer R, Bavari S, Ploegh HL, Anderson DG. Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose. Proc Natl Acad Sci U S A 2016;113:E4133-42.
doi: 10.1073/pnas.1600299113

4

State-of-the-art Cancer Vaccines (Part 1)

See the Lecture Summary

Qian Y, Jin H, Qiao S, Dai Y, Huang C, Lu L, Luo Q, Zhang Z. Targeting dendritic cells in lymph node with antigen peptide-based nanovaccine for immunotherapy. Biomaterials 2016;98:171-83.
doi: 10.1016/j.biomaterials.2016.05.008
5

State-of-the-art Cancer Vaccines (Part 2)

See the Lecture Summary

Tang L, Zheng Y, Melo MB, Mabardi L, Castaño AP, Xie YQ, Li N, Kudchodkar SB, Wong HC, Jeng EK, Maus MV, Irvine DJ. Enhancing T Cell Therapy through TCR-signaling-responsive nanoparticle drug delivery. Nat Biotechnol 2018;36:160-9.
doi: 10.1038/nbt.4181
6

Diagnostic Tools for Infectious Diseases

See the Lecture Summary

Kang DK, Ali MM, Zhang K, Huang SS, Peterson E, Digman MA, Gratton E, Zhao W. Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection. Nat Commun 2014;13:5427.
doi: 10.1038/ncomms6427

Shafiee H, Jahangir M, Inci F, Wang S, Willenbrecht RB, Giguel FF, Tsibris AM, Kuritzkes DR, Demirci, U. Acute on-chip HIV detection through label-free electrical sensing of viral nano-lysate. Small 2013;9:2553-63.
doi: 10.1002/smll.201202195

7

Islet Cell Encapsulation for Diabetes

See the Lecture Summary

Suzuki K, Bonner-Weir S, Trivedi N, Yoon KH, Hollister-Lock J, Colton CK, Weir GC. Function and survival of macroencapsulated syngeneic islets transplanted into streptozocin-diabetic mice. Transplantation 1998;66:21-8.

Vegas AJ, Veiseh O, Doloff JC, Ma M, Tam HH, Bratlie K, Li J, Bader AR, Langan E, Olejnik K, Fenton P, Kang JW, Hollister-Locke J, Bochenek MA, Chiu A, Siebert S, Tang K, Jhunjhunwala S, Aresta-Dasilva S, Dholakia N, Thakrar R, Vietti T, Chen M, Cohen J, Siniakowicz K, Qi M, McGarrigle J, Graham AC, Lyle S, Harlan DM, Greiner DL, Oberholzer J, Weir GC, Langer R, Anderson DG. Combinatorial hydrogel library enables identification of materials that mitigate the foreign body reaction response in primates. Nat Biotechnol 2016;34:345-52.
doi: 10.1038/nbt.3462

8

Visit to Sigilon Therapeutics

See the Lecture Summary

[No Readings]
9

Tissue-instructive Scaffolds

See the Lecture Summary

Ott HC, Matthiesen TS, Goh SK, Black LD, Kren SM, Netoff TI, Taylor DA. Perfusion-decellularized matrix: using nature’s platform to engineer a bioartificial heart. Nat Med 2008;14:213-21.
doi: 10.1038/nm1684

Huang L, Zhu L, Shi X, Xia B, Liu Z, Zhu S, Yang Y, Ma T, Cheng P, Luo K, Huang J, Luo Z. A compound scaffold with uniform longitudinally oriented guidance cues as a porous sheath promotes peripheral nerve regeneration in vivo. Acta Biomater 2018;68:223-36.
doi: 10.1016/j.actbio.2017.12.010

10

Diagnostic Tools for Cancer

See the Lecture Summary

Fan R, Vermesh O, Srivastava A, Yen BK, Qin L, Ahmad H, Kwong GA, Liu CC, Gould J, Hood L, Heath JR. Integrated Blood Barcode Chips. Nat Biotechnol 2008;26:1373-8.
doi: 10.1038/nbt.1507

Che J, Yu V, Garon EB, Goldman JW, Di Carol D. Biophysical isolation and identification of circulating tumor cells. Lab Chip 2017;17:1452-61.
doi: 10.1039/c7lc00038c

11

Low-cost, Paper-based Diagnostic Tools

See the Lecture Summary

Martinez AW, Phillips ST, Whitesides GM. Three-dimensional microfluidic devices fabricated in layered paper and tape. Proc Natl Acad Sci USA 2008;105:19606-11.
doi: 10.1073pnas.0810903105

Dungchai W, Chailapakul O, Henry CS. Electrochemical detection for Paper-Based Microfluidics. Anal Chem 2009;81:5821-6.
doi: 10.1021/ac9007573

12

Non-viral Delivery of Genetic Material for Gene Therapy and Cancer

See the Lecture Summary

Sharei A, Zoldan J, Adamo A, Sim WY, Cho N, Jackson E, Mao S, Schneider S, Han MJ, Lytton-Jean A, Basto PA, Jhunjhunwala S, Lee J, Heller DA, Kang JW, Hartoularos GC, Kim KS, Anderson DG, Langer R, Jensen KF. A vector-free microfluidic platform for intracellular delivery. Proc Natl Acad Sci USA 2013;110:2082-7.
doi: 10.1073/pnas.1218705110

Oberli MA, Reichmuth AM, Dorkin JR, Mitchell MJ, Fenton OS, Jaklenec A, Anderson DG, Langer R, Blankschtein D. Lipid nanoparticle assisted mRNA delivery for potent cancer immunotherapy. Nano Lett 2017;17;1326-35.
doi: 10.1021/acs.nanolett.6b03329

13

Oral Presentations, Conclusion, and Closing Remarks

See the Lecture Summary

[No Readings] 

Course Info

Departments
As Taught In
Fall 2018
Learning Resource Types
Presentation Assignments
Written Assignments