Microbial Megaproducers: Discovery, Biosynthesis, Engineering and Applications of Natural Products

A pie chart showing six different groups of terpene compounds, their chemical structures, their different uses, and the plants from which they are derived.

Terpenes, an example of plant natural products, discussed in Week 10. (Image courtesy of Mariola Zielińska-Błajet and Joanna Feder-Kubis. License: CC BY.)


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Fall 2020



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Course Description

The natural world is a mega-factory of small molecules, peptides, fatty acids, phospholipids, and a host of other compounds, known as natural products (NPs). Immensely diverse in structure and function, NPs have strongly influenced how we treat infectious disease, cancer, pain, and a host of other conditions. Roughly half of the drugs that have been approved in the past 30 years are NPs, derivatives of NPs or NP-inspired. In this discussion-based course, we will delve into research on discovering NPs from producing organisms, investigating the biochemistry of NP production, and using synthetic biology to create NP derivatives—all with a particular emphasis on how genomic data guides and informs all these studies.

This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

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Related Content

Emily Ulrich, and Kenton Hetrick. 7.343 Microbial Megaproducers: Discovery, Biosynthesis, Engineering and Applications of Natural Products. Fall 2020. Massachusetts Institute of Technology: MIT OpenCourseWare, https://ocw.mit.edu. License: Creative Commons BY-NC-SA.

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