7.88J | Spring 2015 | Graduate

Protein Folding and Human Disease

Course Description

This course covers amino acid sequence control of protein folding, misfolding, amyloid polymerization and aggregation. Readings and discussions address topics such as chaperone structure and function, folding and assembly of fibrous proteins, and pathologies associated with protein misfolding and aggregation in …
This course covers amino acid sequence control of protein folding, misfolding, amyloid polymerization and aggregation. Readings and discussions address topics such as chaperone structure and function, folding and assembly of fibrous proteins, and pathologies associated with protein misfolding and aggregation in Alzheimer’s, Parkinson’s, Huntington’s and other protein deposition diseases. Students are required to write and present a research paper.
Learning Resource Types
Projects
Written Assignments
Protein folding factors, illustrated as a series of lines and rectangles folded into different combinations of spirals and shapes.
(Image by MIT OpenCourseWare, adapted from image by Professor Jonathan King.)