Genetic Neurobiology

Readings

SES #	Topics	READINGS
1	Introduction to Course
2	Bacterial Chemoreception
3	Student Presentations	Berg, H. C. “Bacterial microprocessing.” Cold Spring Harb Symp Quant Biol 55 (1990): 539-45. Adler, J. “Chemoreceptors in bacteria.” Science 166, no. 913 (December 26, 1969): 1588-97. Oosawa, K., J. F. Hess, and M. I. Simon. “Mutants defective in bacterial chemotaxis show modified protein phosphorylation.” Cell 53, no. 1 (April 8, 1988): 89-96.
4	Bacterial and Paramecium Motility	Zhang, Y., H. Lu, and C. I. Bargmann. “Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans.” Nature 438, no. 7065 (November 10, 2005): 179-84.
5	Student Presentations	Berg, H. C. “The rotary motor of bacterial flagella.” Annu Rev Biochem 72 (2003): 19-54. Epub December 11, 2002. Blair, D. F., and H. C. Berg. “Restoration of torque in defective flagellar motors.” Science 242, no. 4886 (December 23, 1988): 1678-81. Meister, M., G. Glowe, and H. C. Berg. “The proton flux through the bacterial flagellar motor.” Cell 49, no. 5 (June 5, 1987): 643-50.
6	Neurogenomics: Genome Sequencing and the Nervous System	Carpenter, A. E., and D. M. Sabatini. “Systematic genome-wide screens of gene function.” Nat Rev Genet 5, no. 1 (January 2004): 11-22. Palladino, M. J., L. P. Keegan, M. A. O’Connell, and R. A. Reenan. “A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity.” Cell 102, no. 4 (August 18, 2000): 437-49. Hoopengardner, B., T. Bhalla, C. Staber, and R. Reenan. “Nervous system targets of RNA editing identified by comparative genomics.” Science 301, no. 5634 (August 8, 2003): 832-6.
7	Student Presentations
8	Development of the Nervous System
9	Student Presentations
10	Genetic Analysis of Axonal Pathfinding Student Presentations
11	Genetic Analysis of Membrane Excitability Student Presentations
12	Neurodevelopment and Function in the Mouse	Kano, M., K. Hashimoto, C. Chen, A. Abeliovich, A. Aiba, H. Kurihara, M. Watanabe, Y. Inoue, and S. Tonegawa. “Impaired synapse elimination during cerebellar development in PKC gamma mutant mice.” Cell 83, no. 7 (December 29, 1995): 1223-31. Caviness, V. S. “Reeler mutant mouse: a genetic experiment in developing mammalian cortex.” Soc Neurosci Symp 2 (1977): 27-46.
13	Student Presentations
14	Neurotransmitter Release at Nerve Terminals
15	Student Presentations
16	Genetic Analysis of Sensory Perception
17	Student Presentations
18	Higher Brain Function in Drosophila: Learning and Circadian Rhythms	Konopka, R. J., and S. Benzer. “Clock mutants of Drosophila melanogaster.” Proc Natl Acad Sci U.S.A. 68, no. 9 (September, 1971): 2112-6. Waddell, S., J. D. Armstrong, T. Kitamoto, K. Kaiser, and W. G. Quinn. “The amnesiac gene product is expressed in two neurons in the Drosophila brain that are critical for memory.” Cell 103, no. 5 (November 22, 2000): 805-13.
19	Student Presentations
20	Synapse Formation in Vertebrates and Invertebrates Student Presentations
21	Genetic Analysis of Learning and Memory in Mice
22	Student Presentations	Nakazawa, K., M. C. Quirk, R. A. Chitwood, M. Watanabe, M. F. Yeckel, L. D. Sun, A. Kato, C. A. Carr, D. Johnston, M. A. Wilson, and S. Tonegawa. “Requirement for hippocampal CA3 NMDA receptors in associative memory recall.” Science 297, no. 5579 (July 12, 2002): 211-8. Epub May 30, 2002.
23	Neurogenetics in Humans: Memory and Disease
24	Student Presentations	Millar, J. K., B. S. Pickard, S. Mackie, R. James, S. Christie, S. R. Buchanan, M. P. Malloy, J. E. Chubb, E. Huston, G. S. Baillie, P. A. Thomson, E. V. Hill, N. J. Brandon, J. C. Rain, L. M. Camargo, P. J. Whiting, M. D. Houslay, D. H. Blackwood, W. J. Muir, and D. J. Porteous. “DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.” Science 310, no. 5751 (November 18, 2005): 1187-91.