Biological Chemistry II

An illustration of a cross-section of a small portion of an E. coli cell, showing the cell wall, the cytoplasmic area packed with ribosomes, tRNA, mRNA, enzymes, and the nucleus filled with DNA.

Depiction of macromolecular crowding in E. coli. Illustration by David S. Goodsell, the Scripps Research Institute.


MIT Course Number

5.08J / 7.08J / 7.80

As Taught In

Spring 2016


Undergraduate / Graduate

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Course Description

Course Features

Course Description

This course is an advanced treatment of biochemical mechanisms that underlie biological processes. Topics include macromolecular machines such as the ribosome, the proteasome, fatty acid synthases as a paradigm for polyketide synthases and non-ribosomal polypeptide synthases, and polymerases. Emphasis will be given to the experimental methods used to unravel how these processes fit into the cellular context as well as the coordinated regulation of these processes.

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JoAnne Stubbe, and Elizabeth Nolan. 5.08J Biological Chemistry II. Spring 2016. Massachusetts Institute of Technology: MIT OpenCourseWare, License: Creative Commons BY-NC-SA.

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