Lecture Notes

Part I. Principles of Tissue Engineering: Scaffolds and Cells

Course Overview/Clinical Problems for Tissue Engineering Solution

Introduction to Tissue Engineering in China (PDF)

Scaffolds: Introduction (PDF)

Scaffolds: Collagen-GAG Analogs of Extracellular Matrix (PDF) (Courtesy of Prof. Yannas. Used with permission.)

Prof. Spector, MIT / Prof. Cui, Tsinghua University

Prof. Cui, Tsinghua University

Prof. Spector, MIT

Prof. Yannas, MIT


Cells: Liver Cells (PDF) (Courtesy of Yingxin Xu and Qingling Feng. Used with permission.)

Scaffolds: Recent Advances in Tissue Engineering

Yingxin Xu, M. D., and Qingling Feng Ph. D., Tsinghua University

Prof. Langer, MIT


Scaffolds: Free-Form Manufacturing (PDF 1 of 2 - 2.6 MB)(PDF 2 of 2 - 1.8 MB) (Courtesy of Prof. Yongnian Yan. Used with permission.)

Scaffolds: Self-Assembled Proteins (PDF - 1.2 MB) (Courtesy of Dr. Shuguang Zhang. Used with permission.)

Review (PDF)

Prof. Yan, Tsinghua University

Dr. S. Zhang, MIT

Prof. Spector, MIT


Cells: Sources

Cells: Differentiated versus Stem Cells (PDF)

Dr. C. Vacanti, MIT

Prof. Spector, MIT

Part II. Principles of Tissue Engineering: Cells and Regulators

Scaffolds: Biomimetics Design (PDF)

Cells: Effects of Culture Conditions (PDF) (Courtesy of Dr. Lisa Freed. Used with permission.)

Review (PDF - 1.4 MB)

Prof. Cui, Tsinghua University

Dr. L. Freed, MIT

Prof. Spector, MIT

6 Quiz 1  

Regulators: Response to Mechanical Loading

Regulators: Roles of Environmental Factors

Prof. Grodzinsky, MIT

Dr. Vunjak-Novakovic, MIT


Cells: Embryonic and Other Stem Cell for Tissue Engineering

Gene Therapy

Regulators: Gene Transfer Wedded to Tissue Engineering (PDF) (Courtesy of Prof. Chris Evans. Used with permission.)

Prof. Guo, Tsinghua University

Dr. Zhijie Chang, Tsinghua University

Prof. C. Evans, Harvard Medical School

Part III. Practice of Tissue Engineering: Clinical Applications

Applications: Skin and Peripheral Nerve Regeneration (PDF - 1.0MB) (Courtesy of Prof. Yannas. Used with permission.)

Nerve Repair (PDF - 1.3MB) (Courtesy of Xiufang Zhang, Nanming Zhao, and Yandao Gong. Used with permission.)

Discussion: Clinical Applications (PDF)

Prof. Yannas, MIT

Xiufang Zhang, Nanming Zhao, Yandao Gong, Tsinghua University

Prof. Spector, MIT


Blood Vessels

Heart Valves

Discussion: Comparative Analysis of Tissue Engineering Strategies (PDF)

Prof. Schoen, Harvard Medical School

Dr. W. B. Li, Tsinghua University

Prof. Spector, MIT


Urinary Tissues/Organs

Clinical Applications and Underlying Principles

Prof. Atala, MIT

Prof. Y. Cao, Tsinghua University


Bone Regeneration (PDF) (Courtesy of Yu Xing M. D., Ph. D. Used with permission.)

Cartilage Repair (PDF - 1.0MB)

Discussion: Review (PDF)

Dr. Yu Xing, Tsinghua University, and Prof. Yan Wang, M. D., General Hospital of Peoples' Liberation Army

Prof. Spector, MIT

Prof. Spector, MIT


Federal Regulatory Issues for Tissue Engineering Products in the U.S., China, and Other Countries (PDF)

Brain Repair


Prof. Spector, MIT

Prof. Cui, Tsinghua University

Prof. Spector, MIT / Prof. Cui, Tsinghua University

14 Quiz 2