HST.176 | Fall 2005 | Graduate

Cellular and Molecular Immunology


Course Meeting Times

Lectures: 2 sessions / week, 3 hours / session


Although this is an introductory immunology course, we will deal with the subject in quite some detail which will build as the course progresses. Immunological aspects of disease will be covered in the classroom as well as in case-based tutorial sessions, and in evening clinical discussions at selected teaching hospitals.


Apart from the lectures there will be seven tutorial sessions at which attendance is required. At these sessions immunologically relevant clinical cases will be discussed. The goal will be to use these sessions to review and revise basic immunological issues as well as to get a feel for disease processes. Please see the section in the camel regarding the clinical curriculum.

There will be five tutorial groups each of which will be led by a faculty tutor. Students and individual tutors will remain in the same tutorial group for the duration of the course.


A “basic” textbook and a clinical textbook are recommended. The recommended books are:

Abbas, Abul K., and Andrew Lichtman. Cellular and Molecular Immunology. 6th ed. Philadelphia, PA: Saunders, 2005. ISBN: 9781416023890.

 Rosen, Fred, and Raif Geha. Case Studies in Immunology: A Clinical Companion. 4th ed. New York, NY: Garland Pub., 2004. ISBN: 9780815341024. (Paperback)

Reading of textbook chapters before the class is strongly recommended. For many of the lectures the contents of the slides are summarized in the course camel. The current edition of the following book may also be used:

 Janeway, Charles A., et al. Immunobiology: The Immune System in Health and Disease. New York, NY: Garland Science, 2004. ISBN: 9780443073106.

Exams and Grades

Two short quizzes are planned early in the course to facilitate acquisition of the “language of immunology.” There will be a Mid-term as well as a Final examination (short answers and brief essays). Grades will be based primarily on performance in the quizzes and examinations.

1 Overview - Dr. Shiv Pillai

2 Cells of the Immune System - Dr. Shiv Pillai

3 Lymphocyte Homing - Dr. Ulrich von Andrian

4 Case Presentations at MGH

5 Antibodies and Antigens - Dr. Shiv Pillai

Analyzing a Clinical Case - Dr. Bobby Cherayil

6 Antigen Receptors and the Generation of Diversity - Dr. Shiv Pillai Quiz I
7 Case Presentations at MGH

8 B Lymphocyte Development and Activation - Dr. Shiv Pillai

9 Tutorial Session I

Antibody Dependent Protection - Dr. Shiv Pillai

10 Antigen Presentation - Dr. Hidde Ploegh

11 Tutorial Session II

T Lymphocyte Development - Dr. Shiv Pillai

Quiz II
12 Tutorial Session III

Signal Transduction in Lymphocytes I - Dr. Shiv Pillai

13 Cell Mediated Immunity - Dr. Andrew Lichtman

14 Tutorial Session IV

Signal Transduction in Lymphocytes II - Dr. Shiv Pillai

15 Paper Discussion 1

Midterm Exam

16 Dendritic Cells - Dr. Shannon Turley

Frontiers: Costimulation - Dr. Arlene Sharpe

17 Paper Discussion 2

18 Memory and Death - Dr. Shiv Pillai

Immunology of TB - Dr. Samuel M. Behar

19 Tutorial Session V

Immune Mediated Injury - Dr. Richard Mitchell

20 Asthma and Allergy - Dr. Dale T. Umetsu

Frontiers: DC and Innate Immunity - Dr. Nir Harcohen

21 Multiple Sclerosis - Dr. David Hafler

Frontiers: Autoimmune TCRs - Dr. Kai Wucherpfennig

22 Paper Discussion 3

23 Leukemias and Lymphomas - Dr. Jon C. Aster

CD1 and Lipid Antigens - Dr. Richard S. Blumberg

24 Tutorial Session VI

Transplantation Immunology - Dr. Hugh Auchincloss

25 Immunology of HIV/AIDS - Dr. Bruce Walker

Frontiers: Genetic Instability and Cancer - Dr. Frederick W. Alt

26 Regulatory T Cells - Dr. Diane Mathis

Bone Marrow Transplant - Dr. Megan Sykes

27 Tutorial Session VII

Tumor Immunology - Dr. Andrew Lichtman

28 Paper Discussion 4

29 Regulating Humoral Autoimmunity - Dr. Shiv Pillai

Inflammatory Bowel Disease - Dr. Ramnik Xavier

30 Immunodeficiency Disorders - Dr. Francisco Bonilla

31 RA and Lupus - Dr. Paul Anderson

32 Genetic Susceptibility to Disease - Dr. Shiv Pillai

Final Exam

Course Info

As Taught In
Fall 2005
Learning Resource Types
Lecture Notes