HST.930J | Fall 2005 | Graduate

Social Studies of Bioscience and Biotech


1 Introduction and Overview: Social and Ethical Questions Fischer, Michael M. J. “Four Frameworks for Social and Ethical Questions.” 2005. (PDF)
2 Polymers for Drug Delivery and Tissue Engineering - Prof. Robert Langer, Kenneth J. Germeshausen Professor of Chemical Engineering, MIT Jasanoff, Sheila. Designs on Nature: Science and Democracy in Europe and the United States. Princeton, NJ: Princeton University Press, 2005, introduction, chapter 1, and 2. ISBN: 9780691118116.

Langer, R., and D. A. Tirell. “Designing materials for biology and medicine.” Nature 428, no. 6982 (April 1, 2004): 487-92.

Langer, R. “Where a Pill Won’t Reach.” Sci Am 288, no. 4 (April 2003): 50-7.

3 Embodiment and Structural Biology, Phenomenology of Medicine - Natasha Myers (STS Program, MIT) Myers, Natasha. “Embodiments and the Body-Work of Modeling in Protein Crystallography.” 2005. (Manuscript)

Good, Byron. “The experience of being a medical student.” Chapter 3 in Medicine, Rationality and Experience: An Anthropological Perspective. Cambridge, UK; New York, NY: Cambridge University Press, 1993. ISBN: 9780521415583.

Prentice, Rachel. “The Anatomy of a Surgical Simulation: The Mutual Articulation of Bodies in and through the Machine.” Social Studies of Science 35, no. 6 (2005): 837-866.

4 Tissue Engineering - Dr. Joseph Vacanti, John Homans Professor of Surgery and Director of Pediatric Transplanation, MGH Vacanti, J. P., and R. Langer. “Tissue Engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplanation.” Lancet 354 (1999): 32-34. (Suppl 1)

Langer, R., and J. P. Vacanti. “Tissue Engineering.” Science 260, no. 5110 (May 14, 1993): 920-6.

5 Clinical Narratives - Prof. Mary-Jo DelVecchio Good, Professor of Social Medicine, HMS Good, M. J., I. Kuter, S. Powell, et al. “Medicine on the Edge: Conversations with Oncologists.” Technoscientific Imaginaries: Conversations, Profiles, and Memoirs. Edited by George E. Marcus. Chicago, IL: University of Chicago Press, 1995. ISBN: 9780226504438.

Good, Mary-Jo DelVecchio. American Medicine: the Quest for Competence. Berkeley, CA: University of California Press, 1995, chapter 8, p. 265. ISBN: 9780520088962.

Good, M. J. “The biotechnical embrace.” Cult Med Psychiatry 25, no. 4 (December 2001): 395-410.

6 Photomedicine and Non-invasive Technologies - Dr. R. Rox Anderson, Director Wellman Center for Photomedicine and Professor of Dermatology, MGH, HMS, HST Pitsillides, C. M., E. K. Joe, X. Wei, R. R. Anderson, and C. P. Lin. “Selective cell targeting with light-absorbing microparticles and nanoparticles.” Biophys J 84, no. 6 (June 2003): 4023-4032.

Middelkamp-Hup, M. A., I. Sanchez-Carpintero, S. Kossodo, P. Waterman, S. Gonzalez, M. C. Mihm, Jr., and R. R. Anderson. “Photodynamic therapy for cutaneous proliferative vascular tumors in a mouse model.” J Invest Dermatol 121, no. 3 (September 2003): 634-639.

Manstein, D., G. S. Herron, R. K. Sink, H. Tanner, and R. R. Anderson. “Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury.” Lasers Surg Med 34, no. 5 (2004): 426-438.

Yaroslavsky, A. N, J. Barbosa, V. Neel, C. DiMarzio, and R. R. Anderson. “Combining multispectral polarized light imaging and confocal microscopy for localization of nonmelanoma skin cancer.” J Biomed Opt 10, no. 1 (January-February 2005): 14011.

7 Multidisciplinary Research - Prof. Brian Seed, Professor of Genetics and Health, Science and Technology, Director of Thematic Center for Computational Biology, MGH, HMS, HST Yang, Y., and B. Seed. “Site-specific gene targeting in mouse embryonic stem cells with intact bacterial artificial chromosomes.” Nat Biotechnol 21, no. 4 (April 2003): 447-451.

Randow, F., and B. Seed. “Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability.” Nat Cell Biol 3, no. 10 (October 2001): 891-6.

Kowalczyk, Liz. “Lucrative Licensing Deals with Drugs, Biotech Firms are Raising Ethics Issues for Hospitals.” Boston Globe (March 24, 2002).

“NeoGenesis and Massachussetts General Hospital Announce Drug Discovery Collaboration Agreement.” PRNewswire - Neogenesis, July 23, 2002.

8 Angiogensis; Translation from Bench to Clinic - Dr. Judah Folkman, Andrus Professor of Pediatric Surgery and Professor of Cell Biology, HMS Folkman, J. “Angiogenesis.” In Harrison’s Textbook of Internal Medicine. Edited by E. Braunwald, A. S. Fauci, D. L. Kasper, S. L. Hauser, D. L. Longo, and J. L. Jameson. 15th ed. New York, NY: McGraw-Hill, 2001, pp. 417-530. ISBN: 9780079136862 (set).

ISBN: 9780070072732 (v. 1), and ISBN: 9780070072749 (v. 2).

———. “Fighting cancer by attacking its blood supply.” Sci Am 275, no. 3 (September 1996): 150-4.

———. “Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis.” N Engl J Med 333, no. 26 (December 28, 1995): 1757-63.

9 Stem Cells - Dr. George Q. Daley, M.D./Ph.D., Associate Professor of Biological Chemistry and Molecular Pharmacology, HMS, Children’s Hospital, Brigham and Women’s, and Dana-Farber Daley, G. Q. “Customized human embryonic stem cells.” Nat Biotechnol 23, no. 7 (July 2005): 826-8.

Daley, G. Q., M. J. Sandel, and J. D. Moreno. “Stem cell research: science, ethics and policy.” Med Ethics (Burlington, MA) 12, no. 1 (Winter 2005): 5.

Daley, G. Q. “Missed opportunities in embryonic stem-cell research.” N Engl J Med 351, no. 7 (August 12, 2004): 627-8.

Committee on Guidelines for Human Embryonic Stem Cell Research, Institute of Medicine and National Research Council. “Guidelines for human embryonic stem cell research.” Washington, DC: National Academies Press, 2005.

10 Facilitating Multidisciplinary Research at MGH - Dr. John Parrish, Director MGH-Harvard Cutaneous Biology Research Center, Director of CIMIT, Chief Dermatology Service, MGH, and founding Director Wellman Center for Photomedicine Stokes, Donald E. Pasteur’s Quadrant: Basic Science and Technological Innovation. Washington, DC: Brookings Institution Press, 1997, chapter 1. ISBN: 9780815781783.

Abelmann, Walter H., ed. Harvard-MIT Division of Health Sciences and Technology: The First 25 Years 1970-1995. Cambridge, MA: The Division, 2004. ISBN: 9780674014589.

11 Organ Transplanation in Turkey, Ethical Models of Organ Donation - Aslihan Sanal, STS Program, MIT Sanal, Aslihan. ““Robin Hood” of techno-turkey or organ trafficking in the state of ethical beings.” Culture, Medicine, and Psychiatry 28, no. 3 (September 2004): 281-309.
12 Ethics in Medicine - Prof. Dan Brock, Prof. of Social Medicine and Director of the Division of Medical Ethics, Harvard Medical School  
13 Wrap-up