Cell-Matrix Mechanics

Readings

TOPICS	ADDITIONAL READINGS
Introduction (PDF)	Discher, Dennis E., Paul Janmey, et al. “Tissue Cells Feel and Respond to the Stiffness of their Substrate.” Science 310, no. 5751 (2005): 1139–43. Engler, Adam J., Shamik Sen, et al. “Matrix Elasticity Directs Stem Cell Lineage Specification.” Cell 126, no. 4 (2006): 677–89.
Tissue Structures and Unit Cell Processes (PDF - 3.9MB)	Vale, Ronald D., and Ronald A. Milligan. “The Way Things Move: Looking under the Hood of Molecular Motor Proteins.” Science 288, no. 5463 (2000): 88–95. Stossel, Thomas P. “On the Crawling of Animal Cells.” Science 260, no. 5111 (1993): 1086–94. Hinz, Boris, Giuseppe Celetta, et al. “Alpha-smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity.” Molecular Biology of the Cell 12, no. 9 (2001): 2730–41.
Cell-Matrix Interaction: Integrins and Fibronexus (PDF - 3.9MB)	Ruoslahti, Erkki, and Michael D. Pierschbacher. “New Perspectives in Cell Adhesion: RGD and Integrins.” Science 238, no. 4826 (1987): 491–97. Wang, J. H-C., and B. P. Thampatty. “An Introductory Review of Cell Mechanobiology.” Biomechanics and Modeling in Mechanobiology 5, no. 1 (2006): 1–16.
Extracellular Matrix Molecules [No reading.]	Sweeney, Shawn M., Joseph P. Orgel, et al. “Candidate Cell and Matrix Interaction Domains on the Collagen Fibril, the Predominant Protein of Vertebrates.” Journal of Biological Chemistry 283, no. 30 (2008): 21187–97.
Mechanical Behavior [No reading.]	[There are no additional readings.]
Effects of Exogenous Mechanical Forces (PDF)	Jessop, H. L., M. Sjöberg, et al. “Mechanical Strain and Estrogen Activate Estrogen Receptor α in Bone Cells.” Journal of Bone and Mineral Research 16, no. 6 (2001): 1045–55. Banes, Albert J., Mari Tsuzaki, et al. “Mechanoreception at the Cellular Level: The Detection, Interpretation, and Diversity of Responses to Mechanical Signals.” Biochemistry and Cell Biology 73, no. 7–8 (1995): 349–65. Davies, Peter F., and S. C. Tripathi. “Mechanical Stress Mechanisms and the Cell. An Endothelial Paradigm.” Circulation Research 72, no. 2 (1993): 239–45. Alenghat, Francis J., and Donald E. Ingber. “Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins.” Science STKE 119, no. 6 (2002): pe6. Schaffer, Jonathan L., Michael Rizen, et al. “Device for the Application of a Dynamic Biaxially Uniform and Isotropic Strain to a Flexible Cell Culture Membrane.” Journal of Orthopaedic Research 12, no. 5 (1994): 709–19. McNeil, Paul L., and Richard A. Steinhardt. “Plasma Membrane Disruption: Repair, Prevention, Adaptation.” Annual Review of Cell and Developmental Biology 19, no. 1 (2003): 697–731. Miyake, Katsuya, and Paul L. McNeil. “Mechanical Injury and Repair of Cells.” Critical Care Medicine 31, no. 8 (2003): S496–501. Rubin, Clinton T., and Lance E. Lanyon. “Osteoregulatory Nature of Mechanical Stimuli: Function as a Determinant for Adaptive Remodeling in Bone.” Journal of Orthopaedic Research 5, no. 2 (1987): 300–10.
Endogenous Force Generation by Cells [No reading.]	Freyman, T. M., I. V. Yannas, et al. “Fibroblast Contraction of a Collagen–GAG Matrix.” Biomaterials 22, no. 21 (2001): 2883–91. ———. “Fibroblast Contractile Force is Independent of the Stiffness which Resists the Contraction.” Experimental Cell Research 272, no. 2 (2002): 153–62. Freyman, T. M., I. V. Yannas, et al. “Micromechanics of Fibroblast Contraction of a Collagen–GAG Matrix.” Experimental Cell Research 269, no. 1 (2001): 140–53. Hwang, Kun, Hyung Bo Sim, et al. “Myofibroblasts and Capsular Tissue Tension in Breast Capsular Contracture.” Aesthetic Plastic Surgery 34, no. 6 (2010): 716–21.
Ligaments and Tendons [No reading.]	[There are no additional readings.]
Meniscus and Intervertebral Disc [No reading.]	Walsh, Andrew J. L., and Jeffrey C. Lotz. “Biological Response of the Intervertebral Disc to Dynamic Loading.” Journal of Biomechanics 37, no. 3 (2004): 329–37. Kasra, Mehran, Vijay Goel, et al. “Effect of Dynamic Hydrostatic Pressure on Rabbit Intervertebral Disc Cells.” Journal of Orthopaedic Research 21, no. 4 (2003): 597–603. Fermor, Beverley, Devon Jeffcoat, et al. “[The Effects of Cyclic Mechanical Strain and Tumor Necrosis Factor Alpha on the Response of Cells of the Meniscus](http://dx.doi.org/ 10.1016/j.joca.2004.08.007).” Osteoarthritis and Cartilage 12, no. 12 (2004): 956–62. Zielinska, B., M. Killian, et al. “Meniscal Tissue Explants Response Depends on Level of Dynamic Compressive Strain.” Osteoarthritis and Cartilage 17, no. 6 (2009): 754–60. Zaleskas, J. M., B. Kinner, et al. “Growth Factor Regulation of Smooth Muscle Actin Expression and Contraction of Human Articular Chondrocytes and Meniscal Cells in a Collagen–GAG Matrix.” Experimental Cell Research 270, no. 1 (2001): 21–31.
Articular Cartilage [No reading.]	[There are no additional readings.]
Bone	Hughes-Fulford, Millie. “Signal Transduction and Mechanical Stress.” Science STKE 2004, no. 249 (2004): re12. Turner, Charles H., and Fredrick M. Pavalko. “Mechanotransduction and Functional Response of the Skeleton to Physical Stress: The Mechanisms and Mechanics of Bone Adaptation.” Journal of Orthopaedic Science 3, no. 6 (1998): 346–55. Robling, A. G., K. M. Duijvelaar, et al. “Modulation of Appositional and Longitudinal Bone Growth in the Rat Ulna by Applied Static and Dynamic Force.” Bone 29, no. 2 (2001): 105–13. Burr, D. B., Alexander G. Robling, et al. “Effects of Biomechanical Stress on Bones in Animals.” Bone 30, no. 5 (2002): 781–86.
Biomaterials and Electrically and Magnetically Responsive Matrices [No reading.]	[There are no additional readings.]