22.56J | Fall 2005 | Graduate

Noninvasive Imaging in Biology and Medicine

Readings

Required Textbook

Bushberg, Jerrold T., J. Anthony Seibert, Edwin M. Leidholdt, Jr., and John M. Boone. The Essential Physics of Medical Imaging. 2nd ed. Baltimore, MD: Lippincott Williams & Wilkins, 2001. ISBN: 9780683301182.

Additional Readings

Cho, Z. H., Joie P. Jones, and Manbir Singh. Foundations of Medical Imaging. New York, NY: Wiley-Interscience, 1993. ISBN: 9780471545736.

Phelps, Michael E. PET: Molecular Imaging and Its Biological Applications. New York, NY: Springer, 2004. ISBN: 9780387403595.

Readings by Session

SES # TOPICS READINGS
1 Overview of Imaging

Imaging Radiation

Bushberg. Chapters 1-2.
2 Interactions of Radiation with Matter Bushberg. Chapter 3.
3 X-ray Generation and Planar Imaging Bushberg. Chapter 5-6.
4 X-ray CT Overview Bushberg. Chapter 13.
5 Fourier Transforms and Convolution Cho, et al. Chapter 2.1.
6 Central Slice Theorem and Projection/Reconstruction Cho, et al. Chapter 3.
7 Class Demo: X-ray CT

8 Application: Quantitative Anatomy from CT Class handout
9 Tracers for Nuclear Imaging Bushberg. Chapters 18-19.
10 Nuclear Imaging Detectors and Cameras Bushberg. Chapters 20-21.
11 Principles of PET and SPECT Bushberg. Chapters 22.
12 Application: Binding Measurements with PET Phelps. Chapter 2.
13 Application: Functional Imaging using FDG Uptake Phelps. Chapter 7.
14 Nuclear Magnetic Resonance Physics I Bushberg. Chapter 14.
15 Nuclear Magnetic Resonance Physics II Bushberg. Chapter 14.
16 Magnetic Resonance Imaging I Bushberg. Chapter 15.
17 Magnetic Resonance Imaging II Bushberg. Chapter 15.
18 MRI Contrast Agents Lauffer review
19 Application: BOLD Effect in Functional MRI Class handout
20 Application: Neural Fiber Tracking with MRI Class handout
21 Class Demo: MRI

22 Diffuse Optical Tomography I Class handout
23 Diffuse Optical Tomography II Class handout
24 Optical Molecular Imaging Class handout
25 Final Presentations