8.591J | Fall 2004 | Graduate

Systems Biology

Calendar

LEC # TOPICS KEY DATES
Part I: Systems Microbiology - ‘The Cell as a Well-stirred Bioreactor’
1 Introduction

Michaelis-Menten Kinetics

2 Equilibrium Binding

Cooperativity

3 Lambda Phage

Multistability

4 Multistability (cont.)

5 Synthetic Genetic Switches

6 Stability Analysis

7 Introduction E. coli Chemotaxis

8 Fine-tuned versus Robust Chemotaxis Models Problem set 1 due
9 Wrapping up Chemotaxis

10 Genetic Oscillators

11 Genetic Oscillators (cont.)

12 Stochastic Chemical Kinetics Problem set 2 due
13 Stochastic Chemical Kinetics (cont.)

Part II: Cell Systems Biology - ‘The Importance of Diffusion and Gradients for Cellular Regulation’
14 Introduction Cell Systems Biology

Fick’s Laws

15 Local Excitation

Global Inhibition Theory

16 Local Excitation (cont.)

Global Inhibition Theory (cont.)

Problem set 3 due
17 Rapid Pole-to-pole Oscillations in E. coli

18 Rapid Pole-to-pole Oscillations in E. coli (cont.)

19 Models for Eukaryotic Gradient Sensing Problem set 4 due
20 Models for Eukaryotic Gradient Sensing (cont.)

21 Modeling Cytoskeleton Dynamics

22 Modeling Cytoskeleton Dynamics (cont.) Problem set 5 due
Part III: Developmental Systems Biology - ‘Building an Organism Starting From a Single Cell’
23 Quorum Sensing

24 Final Problem Set Question Hour

25 Drosophila Development Take home final due

Course Info

As Taught In
Fall 2004
Level
Learning Resource Types
Lecture Notes
Problem Sets