Actin-rich processes (light blue) in a transformed fibroblast protruding through extracellular matrix. The yellow spheres represent the centroids of beads added to the matrix to allow measurement of forces generated by the cell as it migrates through the 3D environment. The image shown is a wireframe representation of an isosurface rendering extracted from a time-resolved 3D series. (Image courtesy of Dr. James Evans of the Whitehead-MIT Bioimaging Center. Used with permission.)
This seminar-format course provides an in-depth presentation and discussion of how engineering and biological approaches can be combined to solve problems in science and technology, emphasizing integration of biological information and methodologies with engineering analysis, synthesis, and design. Emphasis is placed on molecular mechanisms underlying cellular processes, including signal transduction, gene expression networks, and functional responses.