This page lists the readings assigned per class session. Chapters from the course textbook are cited as:
[TORA] = Yannas, I. V. Tissue and Organ Regeneration in Adults. New York, NY: Springer, 2001. ISBN: 9780387952147.
| LEC # | TOPICS | READINGS | |
|---|---|---|---|
| I. Tissue environment of the implanted biomaterial: unit cell processes | |||
| 1 | Survey of clinical cases of biomaterials-tissue interactions | Class notes: “Survey of Clinical Cases of Biomaterials-Tissue Interactions: The Paradigm.” (PDF) | |
| 2 |
Tissue structures and unit cell processes Integrins and adhesion proteins |
Class notes: “Tissue Structure/Unit Cell Processes.” (PDF) Giancotti, F. G., and E. Ruoslahti. “Integrin Signaling.” Science 285 (August 13, 1999): 1028-1032. Ruoslathi, E., and M. D. Pierschbacher. “New Perspectives in Cell Adhesion: RGD and Integrins.” Science 238, no. 4826 (October 23, 1987): 491-497. |
|
| 3 | Unit cell processes comprising the healing response |
Class notes: “Unit Cell Processes in the Tissue Environment.” (PDF) Gehrig, L., and M. I. O’Connor. “Putting Sex in Your Orthopaedic Practice.” AAOS Now, June 2008. |
|
| 4 | Unit cell processes underlying tissue engineering | ||
| 5 | Structure and function of naturally occurring ECMs |
Di Lullo, G. A., et al. “Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen.” J Biol Chem 277, no. 6, I (February 8, 2002): 4223-4231. Emsley, J., et al. “Structural Basis of Collagen Recognition by Integrin α2β1.” Cell 101 (March 31, 2000): 47-56. Knight, C. Graham. “The Collagen-binding A-domains of Integrins α1β1 and α2β1 Recognize the Same Specific Amino Acid Sequence, GFOGER, in Native (Triple-helical) Collagens.” J Biol Chem 275, no. 1 (January 7, 2000): 35-40. Darnell, J. E., H. F. Lodish, and D. Baltimore. “Laminin, Fibronectin and Other Multiadhesive Matrix Glycoproteins.” Chapter 23.4 in Molecular Cell Biology. 2nd ed. New York, NY: W. H. Freeman, 1990, pp. 920-924. ISBN: 9780716719816. |
|
| 6 | ECM does not regenerate spontaneously | [TORA], Chapters 1 and 2 | |
| 7 | Quiz 1 | ||
| II. Cell-surface interactions | |||
| 8 | Analysis of surfaces of biomaterials and protein adsorption |
Class notes: “Characteristics of the Surfaces of Biomaterials.” (PDF) Class notes: “Methodology for Chemical Analysis of Surfaces.” (PDF) Ratner, B. D. “Surface Properties of Biomaterials.” In Biomaterials Science: An Introduction to Materials. Edited by B. D. Ratner et al. Burlington, MA: Academic Press, 1996, pp. 21-35. ISBN: 9780125824606. [Preview in Google Books] Andrade, J. D., ed. Excerpts from “Principles of Protein Adsorption.” Chapter 1 in Surface and Interfacial Aspects of Biomedical Polymers, Vol. 2. Protein Adsorption. New York, NY: Plenum Press, 1985. ISBN: 9780306417412. |
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| 9 | Phenotype changes following adhesion on biomaterials | ||
| 10 | Structural determinants of biologically active materials | ||
| 11 | Methodology for cell-surface interactions | ||
| 12 | Cell-scaffold interactions during regeneration |
[TORA], Chapters 9 and 10 Freyman, T. M., I. V. Yannas, R. Yokoo, and L. J. Gibson. “Fibroblast Contraction of a Collagen-GAG Matrix.” Biomaterials 22 (2001): 2883-2891. Freyman, T. M., I. V. Yannas, Y-S. Pek, R. Yokoo, and L. J. Gibson. “Micromechanics of Fibroblast Contraction of a Collagen-GAG Matrix.” Experimental Cell Research 269 (2001): 140-153. Freyman, T. M., I. V. Yannas, R. Yokoo, and L. J. Gibson. “Fibroblast Contractile Force Is Independent of the Stiffness Which Resists the Contraction.” Experimental Cell Research 272 (2002): 153-162. |
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| 13 | Noncooperative cell-surface interactions | ||
| 14 | From randomness to cooperativity | ||
| 15 | Quiz 2 | ||
| III. In vivo and clinical case studies | |||
| 16 | Tissue response to implants; biocompatibility |
Dolores, W., et al. “Cellular and Molecular Composition of Fibrous Capsules Formed Around Silicone Breast Implants with Special Focus on Local Immune Reactions.” Journal of Autoimmunity 23, no. 1 (2004): 81-91. Gordon, S., and P. R. Taylor. “Monocyte and Macrophage Heterogeneity.” Nature Reviews Immunology 5 (December 2005): 953-964. Spector, M., and P. A. Lalor. “In Vivo Assessment of Tissue Compatibility.” Chapter 5.3 in Biomaterials Science: An Introduction to Materials. Edited by B. D. Ratner, et al. Burlington, MA: Academic Press, 1996, pp. 220-228. ISBN: 9780125824606. [Preview in Google Books] |
|
| 17 | Epithelialization (epidermal regeneration) and endothelialization of vascular prostheses |
Buter, C. E., D. P. Orgill, I. V. Yannas, and C. C. Compton. “Effect of Keratinocyte Seeding of Collagen-Glycosaminoglycan Membranes on the Regeneration of Skin in a Porcine Model.” Plastic & Recontructive Surgery 101, no. 6 (May 1998): 1572-1579. |
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| 18 | In vivo synthesis of skin | [TORA], Chapter 5 | |
| 19 | In vivo synthesis of peripheral nerve |
[TORA], Chapter 6 Yannas, I. V., M. Zhang, and M. H. Spilker. “Standardized Criterion to Analyze and Directly Compare Various Materials and Models for Peripheral Nerve Regeneration.” J Biomater Sci, Polymer Edn 18, no. 8 (2007): 943-966. |
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| 20 | Rules for synthesis of tissues and organs | [TORA], Chapter 7 | |
| 21 | Joints and dental tissues: prosthetic replacement | ||
| 22 | Implants for bone regeneration | ||
| 23 | Regeneration of soft musculoskeletal tissues | ||
| 24 | Biomaterial applications in the heart and other organs | ||
| 25 | Quiz 3 | ||
