22.55J | Fall 2004 | Graduate
Principles of Radiation Interactions

Readings

Overview of Cell Biology (PDF)

Rydberg, Björn, William R. Holley, I. Saira Mian, and Aloke Chatterjee. “Chromatin Conformation in Living Cells: Support for a Zig-Zag Model of the 30 nm Chromatin Fiber.” Journal of Molecular Biology 284 (1998): 71-84.

Holley, W. R., I. S. Mian, S. J. Park, B. Rydberg, and A. Chatterjee. “A Model for Interphase Chromosomes and Evaluation of Radiation-Induced Aberrations.” Radiation Research 158 (2002): 568–580.

Dikomey, E., J. Dahm-Daphi, I. Brammer, R. Martensen, and B. Kaina. “Correlation between Cellular Radiosensitivity and Non-repaired Double-strand Breaks Studied in Nine Mammalian Cell Lines.” International Journal of Radiation Biology 73, no. 3 (1998): 269-278.

Löbrich, M., P. K. Cooper, and B. Rydberg. “Non-random Distribution of DNA Double-strand Breaks Induced by Particle Irradiation.” International Journal of Radiation Biology 70, no. 5 (1996): 493-503.

The chapters in the table below are from: Hall, Eric J. Radiobiology for the Radiologist. 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2000. ISBN: 9780781726498.

SES # TOPICS READINGS
1 Course Intro/Cells and Tissues Overview  
2 Radiation Interactions Chapter 1
3 Radiation Interactions (cont.)  
4 Radiation Chemistry/LET/Tracks Chapter 7
5 Effects on Chromosomes/DNA Chapter 2
6 Dose Response in Vitro: Cell Survival Curves Chapter 3
7 RBE/Clustered Damage  
8 Protons and Alphas of same LET  
9 Dose Response in Vivo Chapters 18 and 20
10 Chemical Modification of Radiation Response Chapters 6, 9 and 25
11 Cell, Tissue and Tumor Kinetics Chapters 4 and 5
12 Exam 1  
13 Radiation Therapy: Tumor Radiobiology Chapter 21
14 Radiation Therapy (contd.): Fractionation Chapter 19
15 Acute Effects of Whole Body Exposure Chapter 8
16 Late Effects: Chronic Exposure/Low Doses Chapters 10, 11 and 12
17 Radiation Protection/Background Radiation/Radon Chapter 15
18 Alpha Particles/Bystander Effect  
19 Microbeams  
20 RBE of Diagnostic X Rays  
21 BNCT/Other Modalities Chapters 24, 27 and 28
22 Space  
23 Space (cont.)  
24 Exam 2  
25 Oral Term Paper Presentations  
Course Info