3.051J | Spring 2006 | Undergraduate

Materials for Biomedical Applications

Syllabus

Course Meeting Times

Lectures: 2 sessions / week, 1.5 hours / session

Subject Description

This class provides an introduction to the interactions between cells and the surfaces of biomaterials. The course covers: surface chemistry and physics of selected metals, polymers, and ceramics; surface characterization methodology; modification of biomaterials surfaces; quantitative assays of cell behavior in culture; biosensors and microarrays; bulk properties of implants; and acute and chronic response to implanted biomaterials. General topics include biosensors, drug delivery, and tissue engineering.

Prerequisites

8.01; 8.02; 3.091, 5.111, or 5.112; 7.012, 7.013 or 7.014; 3.012, 5.60, or 2.40.

Texts

Ratner, Buddy D., et al. Biomaterials Science: An Introduction to Materials in Medicine. 2nd ed. Burlington, MA: Academic Press, 2004. ISBN: 9780125824637.

Supplemental Handouts.

Homework

Approximately biweekly (7 problem sets).

Tests

Two quizzes and one final exam.

Grading

ACTIVITIES PERCENTAGES
Homework* 40%
Quiz 1 15%
Quiz 2 15%
Final Exam 30%

* weighting may vary

Note: Students may discuss homework problems, but should write up solutions independently. Quizzes and final are closed-book exams.

Calendar

Several lectures are given by the course TA Dr. Ikuo Taniguchi.

SES # TOPICS ASSIGNMENTS
1

Course Introduction

Biomaterials Defined

Structural Hierarchy in Materials and Biology

Problem set 1 assigned
2

Biomaterials Surfaces: Physics

Surface (vs. Bulk) Structure and Properties

Surface Energy

Adsorption, Segregation, and Reconstruction at Surfaces

 
3

Biomaterials Surfaces: Chemistry

Reactions at Surfaces: Chemisorption, Corrosion

 
4

Biomaterials Surfaces: Chemistry (cont.)

Hydrolysis (Dr. Taniguchi)

Problem set 1 due

Problem set 2 assigned

5

Protein-Surface Interactions

Proteins: Structure, Properties, Functions

Protein Adsorption: Langmuir Model

 
6

Protein-Surface Interactions (cont.)

Protein Adsorption: Complex Phenomena, Measurement

Problem set 2 due

Problem set 3 assigned

7

Cell-Surface Interactions: Host Response to Biomaterials

Cell Adhesion Mechanisms

Coagulation Cascade

 
8

Cell-Surface Interactions: Host Response to Biomaterials (cont.)

Immune Response: Alternative Complement Activation

 
9

Surface Modification Methods

Purposes

Plasma Treatments

Organic Coatings (Dr. Taniguchi)

Problem set 3 due
  Quiz 1  
10

Surface Modification Methods (cont.)

Polymer Coatings

Patterned Surfaces

Problem set 4 assigned
11

Surface Characterization

In Vacuum: XPS/ESCA, AES, SIMS

 
12

Surface Characterization In situ

Contact Angle, AFM

Problem set 4 due
13

Quantifying Cell Behavior

Cell Cultures

Cellular Assays: Adhesion, Migration, Proliferation

Problem set 5 assigned
14

Quantifying Cell Behavior (cont.)

Cellular Assays: Differentiation, Function

 
15

Statistical Analysis

Error Sources, Distribution Functions, t- test

 
16

Statistical Analysis (cont.)

Fisher Test, Regression Methods

Problem set 5 due

Problem set 6 assigned

17

Biosensors and Diagnostic Devices

Biological Elements

Transduction Mechanisms

Properties

Examples: Fiber Optic Biosensors, Nanobarcodes

Problem set 6 due
  Quiz 2  
18

Drug Delivery: Controlled Release (Dr. Taniguchi)

Chemically-controlled Devices

 
19

Drug Delivery: Controlled Release (cont.)

Diffusion-controlled, Membrane-based and Osmotic Devices

Problem set 7 assigned
20

Drug Delivery: Controlled Release (cont.)

Methods: Transdermal, Colloidal Vehicles

Mechanical Pumps

 
21

Biomaterials for Organ Replacement

Organ Replacement Therapies

Mechanical Properties

Bone Substitutes

 
22

Tissue Engineering
Cell Types; Approaches: In vitro, In vivo, Ex vivo/Cell Encapsulation

Scaffolds: Design and Fabrication

Problem set 7 due
23

Tissue Engineering (cont.)

Case Examples: Artificial Pancreas, Cartilage, Nerve Regeneration

 
24 FDA Regulatory Issues and Course Evaluations  
  Final Exam  

Course Info

Instructor
As Taught In
Spring 2006
Learning Resource Types
Exams with Solutions
Lecture Notes
Problem Sets with Solutions