Required Text
[S&K] Shuler, Michael L., and Fikret Kargi. Bioprocess Engineering: Basic Concepts. 2nd ed. Upper Saddle River, NJ: Prentice Hall PTR, 2001. ISBN: 9780130819086.
Additional Resources
Blanch, Harvey W., and D. S. Clark, eds. Biochemical Engineering. New York, NY: Marcel Dekker Incorporated, 1997. ISBN: 9780824700997.
Bailey, James E., and David F. Ollis. Biochemical Engineering Fundamentals. New York, NY: McGraw-Hill Education, 1986. ISBN: 9780070666016.
Rozzell, J. D. “Commercial scale biocatalysis: myths and realities.” Bioorg Med Chem 7, no. 10 (October 1999): 2253-61.
| SES # | TOPICS | READINGS |
|---|---|---|
| 1 | Course Overview, Enzyme Classification | S&K. Chapter 1. |
| 2 | Enzyme Kinetics (Single-substrate Reactions), Measurement | S&K. Chapter 3.1-3.3.3. |
| 3 | Enzyme Inhibition | S&K. Chapter 3.3.4. |
| 4 | Enzyme Inhibition, pH and Temp Effects | S&K. Chapter 3.3.5. |
| 5 | Non-ideal Enzyme Kinetics | Class notes |
| 6 | Immobilized Enzyme Kinetics - External | S&K. Chapter 3.4. |
| 7 | Immobilized Enzyme Kinetics - Internal | S&K. Chapter 3.4. |
| 8 | Applications of Enzyme Catalysis (Biocatalysis) |
S&K. Chapter 3.5, 3.6.
Handouts |
| 9 | Microbial Growth | S&K. Chapter 6.1-6.2. |
| 10 | Microbial Growth - Batch Cultivation Profiles | S&K. Chapter 6.1-6.2. |
| 11 | Stoichiometry of Growth, Product Formation | S&K. Chapter 7. |
| 12 | Stoichiometry of Growth, Product Formation (cont.) | S&K. Chapter 7. |
| 13 | Models of Microbial Growth | S&K. Chapter 6.3. |
| 14 | Models of Microbial Growth (cont.) | S&K. Chapter 6.3. |
| 15 | Continuous Culture | S&K. Chapter 6.4. |
| 16 | Continuous Culture (cont.) | S&K. Chapter 6.4. |
| 17 | Bioreactor Design | S&K. Chapter 9.1-9.3. |
| 18 | Bioreactor Design (cont.) | S&K. Chapter 9.1-9.3. |
| 19 | Bioreactor Design (cont.) | |
| 20 | Mass Transfer | S&K. Chapter 6.2.3-6.2.4, 10.2.3. |
| 21 | Mass Transfer (cont.) | S&K. Chapter 6.2.3-6.2.4, 10.2.3. |
| 22 | Heat Transfer, Media and Air Sterilization | S&K. Chapter 10.4. |
| 23 | Scale-up | S&K. Chapter 10.2.4. |
| 24 | Scale-down | S&K. Chapter 10.2.5. |
| 25 | Animal Cell Culture | S&K. Chapter 12. |
| 26 | Animal Cell Culture (cont.) | S&K. Chapter 12. |
| 27 | Mixed Cultures | S&K. Chapter 16. |
| 28 | Mixed Cultures (cont.) | S&K. Chapter 16. |
| 29 | Medium Development | Handouts |
| 30 | Medium Development (cont.) | Handouts |
| 31 | Cellular Engineering - An Engineer’s View Towards Recombinant Organisms |
S&K. Chapter 14.
Handouts |
| 32 | Cellular Engineering/Molecular Biology for Process Engineering |
S&K. Chapter 14.
Handouts |
| 33 | Cellular Engineering/Molecular Biology for Process Engineering (cont.) |
S&K. Chapter 14.
Handouts |
| 34 | Enzyme Engineering for Process Improvement | Handouts |
| 35 | Enzyme Engineering for Process Improvement (cont.) | Handouts |
