Lecture Notes

1 Important Role of Water Molecule, Hydration of Amino Acids, Protein and other Biological Materials (PDF)
2 Amino Acids: Their Chemical and Physical Properties (PDF)
3 Primary and Secondary Structures of Proteins

Dihedral Angles, Peptide Bonds, Planar Structure, Relationship and Propensity of Amino Acid Sequence, Secondary Structure

Ramachandran Plot

4 Alpha-helices, 310 Helix, pi Helix, Beta-helices, etc.

Variation of Helices and their Helical Bundles, Two Strand Coiled-coils, Three or Four Strand Coiled-coils, Supercoils

Various Helical Rich Protein Structure Models

Alpha-helices in Biological Materials

5 Helical Coiled-coils

Two-, Three-, Four- Stranded Helical Bundles

Applying Coiled-coils to Nanomaterials, Molecular Springs, Switches, etc.

6 Beta Sheets: Antiparallel, Parallel, and Twist; Beta Sheet Rich Proteins; Beta Sheets in Biological Materials (PDF)
7 Practical Aspects of Single Crystal X-ray Crystallography, Part 1: X-ray Single Crystal Diffraction, Fiber Diffraction, and Preparation of Samples (PDF)
8 NMR (Guest Lecturer: Peter Carr, MIT Media Lab) (PDF)
9 Practical Aspects of Single Crystal X-ray Crystallography, Part 2 (PDF)
10 Analytical Approaches and Instrumentation (Guest Lecturer: Sotirus Koutsopoulos, Ph.D) (PDF)
11 Silk (PDF)
12 Biomineralization: Sea Creatures (PDF)
13 Biomineralization: Bones and Teeth (PDF)
14 Bioadhesives (PDF)
15 Lipids as Building Materials (PDF)
16 Polysaccharides and Oligosaccharides (PDF)
17 Francis Crick Film
18 Molecular Structure and Self-assembly of DNA and RNA (PDF)
19 Macromolecular Interactions and Protein and Adsorption (Guest Lecturer: Larry Unsworth, Ph.D, National Institute for Nanotechnology) (PDF)

Crystallography (Guest lecturer: Liselotte Kaiser, MIT Center for Biomedical Engineering)

20 DNA Molecular Machines (PDF)
21 Fluorescent Proteins (PDF)
22 Self-assembling Peptide Systems (Dr. Zhang’s Research) (PDF)
23 Self-assembling Peptide Systems (Dr. Zhang’s Research) (cont.) (PDF)

Applying Biomimicry to Nanotechnology (Guest Lecture by Andreas Mershin)

24 Research in Biomaterials (PDF)
25-26 Student Research Activity Presentations

Course Info

As Taught In
Fall 2005
Learning Resource Types
Lecture Notes
Presentation Assignments with Examples
Written Assignments with Examples