Lecture Notes

This page presents the lecture notes for each class session, plus supporting multimedia for some sessions.

LEC # TOPICS SUPPORTING MULTIMEDIA
1 Introduction to nanomechanics ( PDF ) Feynman, Richard. Tiny Machines. Audio CD, Sound Photosynthesis, 1984.
2 High resolution force spectroscopy (HRFS): The force transducer ( PDF )  
3 Additional nanomechanics instrumentation components ( PDF )  
4 Force versus distance curves ( PDF )  
5 Atomic force microscope (AFM) imaging ( PDF )

Video: “Understanding AFM”
( MP4 - 109 MB )
(Courtesy of Asylum Research, Inc. Used with permission)

Force curve animation, from NC State University (MOV)

6 AFM imaging II: Artifacts and applications ( PDF )  
7 Single cell mechanics ( PDF )  
8 Qualitative Introduction to intra- and intermolecular forces ( PDF ) Protein Folding demo [You will need the MDL Chime plugin for your browser, which is a free download.]
9 Quantitative description of intra- and intermolecular forces ( PDF )  
10 Molecule-surface interactions ( PDF )  
11 Colloids and interparticle potentials ( PDF )  
12 Van der Waals forces at work: Gecko feet adhesion ( PDF )  
13 Midterm exam solutions review ( PDF )  
14 The electrical double layer (EDL) - part 1 ( PDF )  
15 The electrical double layer (EDL) - part 2 ( PDF )  
16 Nanomechanics of cartilage ( PDF - 2.0 MB )  
17 Protein-surface interactions ( PDF - 1.3 MB )

John Marko, Cornell University, 1994.

Simulation of Polymer Brush Interacting with Nanosized Object ( AVI ) (Courtesy of Jan Hoh. Used with permission.)

18 Nanomechanics and biocompatibility: Protein-biomaterial interactions, part 2 ( PDF ) Same as prior session.
19 Elasticity of single polymer chains: Theoretical formulations ( PDF )  
20 Theoretical aspects of single molecule force spectroscopy: Extensibility and the worm-like chain (WLC) ( PDF )  
21 Single chain elasticity of biomacromolecules: The giant protein titin and DNA ( PDF )

From the Theoretical and Computational Physics Group, UIUC:

Movie of SMFS Fibronectin stretching ( MPEG - 1.7 MB )

Simulations of unfolding titin immunoglobulin domains

22 Theoretical aspects of nanoindentation ( PDF )  
23 Nanoindentation 2: Oliver-Pharr method and one literature example: Nacre ( PDF - 1.0 MB )  
24 Intermolecular interactions in motility of a biological spring (guest lecture by Danielle France, course TA)  

Course Info

Learning Resource Types

theaters Demonstration Videos
theaters Simulation Videos
notes Lecture Notes
grading Exams with Solutions
assignment_turned_in Written Assignments with Examples