3.052 | Spring 2007 | Undergraduate

Nanomechanics of Materials and Biomaterials

Lecture Notes

This page presents the lecture notes for each class session, plus supporting multimedia for some sessions.

1 Introduction to nanomechanics (PDF) Feynman, Richard. Tiny Machines. Audio CD, Sound Photosynthesis, 1984.
2 High resolution force spectroscopy (HRFS): The force transducer (PDF)  
3 Additional nanomechanics instrumentation components (PDF)  
4 Force versus distance curves (PDF)  
5 Atomic force microscope (AFM) imaging (PDF)

Video: “Understanding AFM”
(MP4 - 109 MB)
(Courtesy of Asylum Research, Inc. Used with permission)

Force curve animation, from NC State University (MOV)

6 AFM imaging II: Artifacts and applications (PDF)  
7 Single cell mechanics (PDF)  
8 Qualitative Introduction to intra- and intermolecular forces (PDF) Protein Folding demo [You will need the MDL Chime plugin for your browser, which is a free download.]
9 Quantitative description of intra- and intermolecular forces (PDF)  
10 Molecule-surface interactions (PDF)  
11 Colloids and interparticle potentials (PDF)  
12 Van der Waals forces at work: Gecko feet adhesion (PDF)  
13 Midterm exam solutions review (PDF)  
14 The electrical double layer (EDL) - part 1 (PDF)  
15 The electrical double layer (EDL) - part 2 (PDF)  
16 Nanomechanics of cartilage (PDF - 2.0 MB)  
17 Protein-surface interactions (PDF - 1.3 MB)

John Marko, Cornell University, 1994.

Simulation of Polymer Brush Interacting with Nanosized Object (AVI) (Courtesy of Jan Hoh. Used with permission.)

18 Nanomechanics and biocompatibility: Protein-biomaterial interactions, part 2 (PDF) Same as prior session.
19 Elasticity of single polymer chains: Theoretical formulations (PDF)  
20 Theoretical aspects of single molecule force spectroscopy: Extensibility and the worm-like chain (WLC) (PDF)  
21 Single chain elasticity of biomacromolecules: The giant protein titin and DNA (PDF)

From the Theoretical and Computational Physics Group, UIUC:

Movie of SMFS Fibronectin stretching (MPEG - 1.7 MB)

Simulations of unfolding titin immunoglobulin domains

22 Theoretical aspects of nanoindentation (PDF)  
23 Nanoindentation 2: Oliver-Pharr method and one literature example: Nacre (PDF - 1.0 MB)  
24 Intermolecular interactions in motility of a biological spring (guest lecture by Danielle France, course TA)  

Course Info

As Taught In
Spring 2007
Learning Resource Types
Demonstration Videos
Simulation Videos
Lecture Notes
Exams with Solutions
Written Assignments with Examples