|LEC #||TOPICS||STUDY MATERIALS|
|1||Introduction to nanomechanics||
Richard Feynman biography from the MacTutor History of Mathematics archive
Drexler, K. Eric. Engines of Creation: The Coming Era of Nanotechnology. (1986).
Crichton, Michael. Prey. New York, NY: Harper Collins, 2003. ISBN: 9780007154531.
|2||High resolution force spectroscopy (HRFS): The force transducer||
French, A. P. “Periodic Motions,” “The Free Vibrations of Physical Systems,” and “Forced Vibrations and Resonance.” Chapters 1, 3, and 4 in Vibrations and Waves. New York, NY: W.W. Norton & Co., 1971. ISBN: 9780393099362.
Rugar, D., et al. “Adventures in Attonewton Force Detection.” Appl Phys A 72 [Suppl.] (2001): S3-S10.
Vettiger, P., et al. “The ‘Millipede’ - More Than One Thousand Tips for Future AFM Data Storage.” IBM J Res Develop 44, no. 3 (May 2000): 323-340.
Beer, F., E. R. Johnston, and J. T. DeWolf. “Pure Bending,” “Analysis and Design of Beams for Bending,” and “Deflection of Beams.” Chapters 4, 5, and 9 in Mechanics of Materials. 4th ed. New York, NY: McGraw-Hill, 2005. ISBN: 9780073107950.
Molloy, J. E., and M. J. Padgett. “Lights, Action: Optical Tweezers.” Contemporary Physics 43, no. 4 (2002): 241-258.
Let there be light. Audio program on optical tweezers from BBC “Science Frontiers.” (10/29/2003, 30 min)
|3||Additional nanomechanics instrumentation components||
Domke, J., et al. “Mapping the Mechanical Pulse of Single Cardiomyocytes with the Atomic Force Microscope.” Eur Biophys J 28 (1999): 179-186.
Guo, X. E., et al. “Intracellular Calcium Waves in Bone Cell Networks Under Single Cell Nanoindentation.” MCB 3, no. 3 (2006): 95-107.
Roylance, D. E. “Matrix and Index Notation.” From 3.11 Mechanics of Materials, Fall 1999, MIT OpenCourseWare. [Refer to the piezoelectricity equations.] ( PDF)
Shusteff, M., T. P. Burg, and S. R. Manalis. “Measuring Boltzmann’s Constant with a Low-Cost Atomic Force Microscope: An Undergraduate Experiment.” Am J Phys 74, no. 10 (October 2006): 873-9.
|4||Force versus distance curves|
|5||Atomic force microscope (AFM) imaging||
AFM model (Lehigh University) ( EXE) (Courtesy of Joseph Griffith. Used with permission.)
|6||AFM imaging II: Artifacts and applications|
|7||Single cell mechanics|
|8||Qualitative introduction to intra - and intermolecular forces||
Review of definitions for intra- and intermolecular interactions ( PDF)
Hartgerink, J. D., et al. “Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers” Science 294, no. 5547 (November 23, 2001): 1684-1688.
Dissolving of salt by water simulation (Wellesley College)
Van der Waals animation (Wellesley College)
|9||Quantitative description of intra - and intermolecular forces|
|10||Molecule - surface interactions||Solutions to integrals shown in lecture ( PDF)|
|11||Colloids and interparticle potentials||
Lewis, J. A. “Colloidal Processing of Ceramics.” J Am Ceram Soc 83, no. 10 (2000): 2341-59.
Israelachvili, J. “Chord Theorem.” In Intermolecular Forces. 2nd ed. p. 143.
|12||Van der Waals forces at work: Gecko feet adhesion|
|13||Midterm exam solutions review|
|14||The electrical double layer (EDL) - part 1||
EDL length scales ( PDF)
Electrostatics definitions ( PDF)
|15||The electrical double layer (EDL) - part 2|
|16||Nanomechanics of cartilage||Nanomechanics of cartilage: Definitions ( PDF)|
|17||Protein - surface interactions|
|18||Nanomechanics and biocompatibility: protein - biomaterial interactions, part 2||Halperin, A. “Polymer Brushes that Resist Adsorption of Model Proteins: Design Parameters.” Langmuir 15 (1999): 2525-2533.|
|19||Elasticity of single polymer chains: Theoretical formulations|
|20||Theoretical aspects of single molecule force spectroscopy: Extensibility and the worm-like chain (WLC)|
|21||Single chain elasticity of biomacromolecules: The giant protein titin and DNA|
|22||Theoretical aspects of nanoindentation|
|23||Nanoindentation 2: Oliver-Pharr method and one literature example: Nacre|
|24||Intermolecular interactions in motility of a biological spring (guest lecture by Danielle France, course TA)|
Learning Resource Types
theaters Demonstration Videos
theaters Simulation Videos
notes Lecture Notes
grading Exams with Solutions
assignment_turned_in Written Assignments with Examples