Laboratory Chemistry

Readings

Required Text

[MHS] = Mohrig, Alberg, et al. Laboratory Techniques in Organic Chemistry. 4^th ed. W. H. Freeman, 2014. ISBN: 9781464134227.

Recommended

[SWH] = Skoog, West, et al. Fundamentals of Analytical Chemistry. 9^th ed. Brooks Cole, 2013. ISBN: 9780495558286. [Preview with Google Books]

[S&L] = Skoog, Holler, and Crouch. Principles of Instrumental Analysis. 6^th ed. CL, 2007. ISBN: 9788131525579.

[Oxtoby] = Gillis, and Campion. Principles of Modern Chemistry. 7^th ed. Cengage Learning, 2012. ISBN: 9780840049315.

[Atkins] = Jones, and Laverman. Chemical Principles: The Quest for Insight. 6^th ed. W. H. Freeman, 2012. ISBN: 9781429288972.

[SFH] = Steinfeld, Joesph S. Francisco, and Wiliam L. Hase. Chemical Kinetics and Dynamics. 2^nd ed. Pearson, 1998. ISBN: 9780137371235.

[JWZ] = Zubrick. The Organic Chem Lab Survival Manual: A Student’s Guide to Techniques. 10^th ed. Wiley, 2016. ISBN: 9781118875780.

[C&G] = Coghill, and Garson, eds. The ACS Style Guide: Effective Communication of Science Information. 3^rd ed. American Chemical Society, 2006. ISBN: 9780841239999.

TOPICS	READINGS
Introduction	Lab Manual: Sections I, II, III, and Experiment 2 (Ellen Swallow Richards Lab) [MHS] Chapter 1: Safety, pp. 3–21. [MHS] Chapter 3: Laboratory Notebook, pp. 32–39. [MHS] Chapter 4: Laboratory Glassware, pp. 44–51. [MHS] Chapter 5: Measuring Mass and Volume & Transfers, pp. 52–72. [MHS] Chapter 6: Heating Methods & Cooling Methods, pp. 73–86. [MHS] Chapter 13: Using the Literature of Organic Chemistry, pp. 501–506. [SWH] “Balances.” pp. 23–30 (pp. 797–806). Optional [JWZ] Chapter 13: Buchner Funnels and Filtration, pp. 107–113.
Ellen Swallow Richards Lab	[MHS] Chapter 5: Measuring Mass and Volume, pp. 52–64. [SWH] Chapter 20: Standard Reducing Agents, Thiosulfate Solutions, pp. 511–514. [SWH] Chapter 23: Dissolved Oxygen, pp. 681–682. [SWH] “Phosphate Ion Determination FIA.” pp. 1059–1061. [MHS] Chapter 25: UV & VIS Spectroscopy, pp. 465–475. Michaud, Joy. Chapter 4 in A Citizens Guide to Understanding and Monitoring Lakes and Streams (PDF – 7.4MB). Puget Sound Water Quality Authority, 1991, pp. 45–58.  Review [Oxtoby] Chapter 20.1–20.2: General Aspects of Molecular Spectroscopy. [Oxtoby] Chapter 20.5: Excited Electronic States. [Oxtoby] Chapter 8.5: The Spectrochemical Series. OR [Atkins] Chapter: 4.12: Orbitals in Polyatomic Molecules, pp. 139–140. [Atkins] Chapter: 17.8: The Electronic Structures of Complexes, pp. 749–759. Read [SWH] Chapter: 26: Molecular Absorption Spectroscopy, pp. 723–759. Optional [SWH] Chapter: 25: Instruments for Optical Spectroscopy. OR [S&L] Chapter 6: Intro to Spectrometric Methods, pp. 132–135, 141–144, and 157–159. [S&L] Chapter 14: Application of UV/VIS spectroscopy, pp. 367–374. Optional [S&L] Chapter 8: Instruments for Optical Spectroscopy, pp. 215–228.
Error Analysis	[MHS] Chapter 5.5: Measurement Uncertainty & Error Analysis, pp. 64–73. [SWH] Chapter 5: Errors in Chemical Analysis. [SWH] Chapter 6: Random Errors in Chemical Analysis. [SWH] Chapter 7: Statistical Evaluation of Data. OR [S&L] Appendix 1: Evaluation of Analytical Data, pp. 967–993.
Writing Reports	[C&G] The ACS Style Guide.
Ferrocene Lab Chromatography	Lab Manual: Experiment 1 (Ferrocene). [MHS] Chapter 12: Boiling Point & Distillation, pp. 173–205. [MHS] Chapter 6: Heating & Cooling Methods, pp .73–86. [MHS] Chapter 7: Setting Up Organic Reactions, pp. 87–106. [MHS] Chapter 16: Sublimation, pp. 236–239. [MHS] Chapter 5: Transfer of Reagents Using a Syringe, pp. 59–61. [Oxtoby] Chapter 10.6: Phase Diagrams, pp. 462–465. OR [Atkins] Chapter 10.6: Phase Diagrams, pp. 375–378. [MHS] Chapter 18: Thin-Layer Chromatography, pp. 255–267. [MHS] Chapter 19: Liquid chromatography, pp. 270–291. [Oxtoby] Chapter 14.8: Distribution of a Single Species between Immiscible Phases: Extraction and Separation Processes, pp. 650–654. OR [Atkins] Major Technique 4 Chromatography F59.
Essential Oils Lab Infrared Spectroscopy Chromatography Refractometry/Polarimetry	Lab Manual: Experiment 3 (Essential Oils) [MHS] Chapter 12: Boiling Points and Distillation, pp. 173–205. [Oxtoby] Chapter 11.6: Mixtures and Distillation, pp. 499–504. OR [Atkins] Chapter 10.15: Vapor Pressure Lowering, pp. 392–394. [Atkins] “Binary Liquid Mixtures.” pp. 402–440. [MHS] Chapter 21: Infrared Spectroscopy, pp. 311–344. [Oxtoby] Chapter 20.3: Vibrations and Rotations of Molecules. OR [Atkins] “Major Technique 1 Infrared Spectroscopy.” pp. 105–106. Optional [S&L] Chapter 12: Infrared Absorption Spectroscopy. [MHS] Chapter 20: Gas Chromatography, pp. 291–308. [MHS] Chapter 13: Refractometry, pp. 206–211. [MHS] Chapter 17: Optical Activity and Polarimetry, pp. 240–251. [Atkins] Box 17.2 and Figure 16.25 Optical activity, Plane polarized light, p. 746.
Fischer Esterification Lab Refluxing NMR Mass Spectroscopy Infrared Spectroscopy	Lab Manual: Experiment 4 (Fischer Esterification) [MHS] Chapter 5: Measuring Mass & Volume, Using Pasteur Pipettes, Thermometer Calibration, pp. 52–63. [MHS] Chapter 7: Refluxing a Reaction Mixture, pp. 59–60. [MHS] Chapter 11: Extraction: Separatory Funnel, pp. 113–124. [MHS] Chapter 12: Boiling Point & Distillation, pp. 174–176. [MHS] Chapter 13: Refractive Index, pp. 206–211. [MHS] Chapter 21: Infrared Spectroscopy, pp. 311–344. [MHS] Chapter 22: Nuclear Magnetic Resonance, pp. 350–405. [MHS] Chapter 24: Mass Spectrometry, pp. 441–462. [Atkins] Chapter 10: Distillation, pp. 404–406. [Atkins] Chapter 10.3: Clausius-Clapeyron Equation, pp. 371–373. [Atkins] Chapter 10.4: Boiling, pp. 373–374. [Atkins] Chapter 20: Esters, pp. 828–829.
Catalase Kinetics Lab	Lab Manual: Experiment 5 (Catalase Kinetics) [SFH] “Definition of the Rate of a Chemical Reaction.” pp. 1–3. [SFH] “Order and Molecularity of a Reaction.” pp. 3–6. [SFH] “Reaction Mechanisms.” pp. 17–18. [SFH] “Enzyme-Catalyzed Reactions.” pp. 159–163. [MHS] “Measuring Mass and Volume.” pp. 52–61. [MHS] “Heating and Cooling Methods.” pp. 73–86. [SWH] “Rates of Chemical Reaction.” pp. 879–884. [SWH] “Enzyme-Catalyzed Reactions.” pp. 885–892. [MHS] Chapter 25: UV & VIS Spectroscopy, pp. 465–487. OR [Atkins] Chapter 4.12: Orbitals in Polyatomic Molecules, pp. 139–140. [Atkins] Chapter 17.8: The Electronic Structures of Complexes, pp. 749–759. Read [SWH] Chapter 26: Molecular Absorption Spectroscopy, pp. 723–759. Optional [SWH] Chapter 25: Instruments for Optical Spectroscopy. OR [S&L] Chapter 6: Intro to Spectrometric Methods, pp. 132–135, 141–144, and 157–159. [S&L] Chapter 14: Application of UV/VIS spectroscopy, pp. 367–374. Optional [S&L] Chapter 8: Instruments for Optical Spectroscopy, pp. 215–228.