Readings

The assigned readings below are discussed at the journal club meetings during the semester. Supplemental papers are listed at the bottom.

SES # READINGS
Journal Club 1, Ses 13

Main Paper

Sengupta, P., J. H. Chou, et al. “odr–10 Encodes a Seven Transmembrane Domain Olfactory Receptor Required for Responses to the Odorant Diacetyl.” Cell 84, no. 6 (1996): 899–909.

Additional Reading

Bargmann, C. I., E. Hartwieg, et al. “Odorant–selective Genes and Neurons Mediate Olfaction in C. elegans.” Cell 74, no. 3 (1993): 515–27.

Troemel, E. R., B. E. Kimmel, et al. “Reprogramming Chemotaxis Responses: Sensory Neurons Define Olfactory Preferences in C. elegans.” Cell 91, no. 2 (1997): 161–9.

Journal Club 2, Ses 18

Main Paper

Cabreiro, F., C. Au, et al. “Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism.” Cell 153, no. 1 (2013): 228–39.

Additional Readings

Pernicova, I., and M. Korbonits. “Metforminmode of Action and Clinical Implications for Diabetes and Cancer.” Nature Reviews Endocrinology 10, no. 3 (2014): 143–56.

Clemente, J. C., L. K. Ursell, et al. “The Impact of the Gut Microbiota on Human Health: An Integrative View.” Cell 148, no. 6 (2012): 1258–70.

Journal Club 3, Ses 28

Main Paper

Meisel, J. D., O. Panda, et al. “Chemosensation of Bacterial Secondary Metabolites Modulates Neuroendocrine Signaling and Behavior of C. elegans.” Cell 159, no. 2 (2014): 267–80.

Additional Readings

Price–Whelan, A., L. E. Dietrich, et al. “Rethinking ‘Secondary’ Metabolism: Physiological Roles for Phenazine Antibiotics.” Nature Chemical Biology 2, no. 2 (2006): 71–8.

Prasad, Brinda C., and Randall R. Reed. “Chemosensation: Molecular Mechanisms in Worms and Mammals.” Trends in Genetics 15, no. 4 (1999): 150–3.

Journal Club 4, Ses 43

Main Paper

Ghosh, R., E. C. Andersen, et al. “Natural Variation in a Chloride Channel Subunit Confers Avermectin Resistance in C. elegans.” Science 335, no. 6068 (2012): 574–8.

Additional Readings

Andersen, E. C., J. P. Gerke, et al. “Chromosome–scale Selective Sweeps Shape Caenorhabditis Elegans Genomic Diversity.” Nature Genetics 44, no. 3 (2012): 285–90.

Manolio, T. A., et al. “Finding the Missing Heritability of Complex Diseases.” Nature 461, no. 7265 (2009): 747–53.

Journal Club 5, Ses 48

Main Paper

Costanzo, M., A. Baryshnikova, et al. “The Genetic Landscape of a Cell.” Science 327, no. 5964 (2010): 425–31.

Additional Reading

J. L., HartmanIV, Garvik B., et al. “Principles for the Buffering of Genetic Variation.” Science 291, no. 5506 (2001): 1001–4.

Chan, D. A., and A. J. Giaccia. “Harnessing Synthetic Lethal Interactions in Anticancer Drug Discovery.” Nature Reviews Drug Discovery 10, no. 5 (2011): 351–64.

Journal Club 6, Ses 53

Main Paper

Wang, T., J. J. Wei, et al. “Genetic Screens in Human Cells Using the CRISPR–Cas9 System.” Science 343, no. 6166 (2014): 80–4.

Additional Reading

Cong, L, et al. “Multiplex Genome Engineering Using CRISPR/Cas Systems.” Science 339, no. 6121 (2013): 819–23.

Barrangou, R., and L. A. Marraffini. “CRISPR–Cas Systems: Prokaryotes Upgrade to Adaptive Immunity.” Molecular Cell 54, no. 2 (2014): 234–44.

Journal Club 7, Ses 58

Main Paper

Weinreich, D. M., N. F. Delaney, et al . “[Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins](http://dx.doi.org/ 10.1126/science.1123539).” Science 312, no. 5770 (2006): 111–4.

Additional Reading

Tokuriki, N., and D. S. Tawfik. “Protein Dynamism and Evolvability.” Science 324, no. 5924 (2009): 203–7.

Journal Club 8, Ses 63

Main Paper

Holmes, D. L., A. K. Lancaster, et al. “Heritable Remodeling of Yeast Multicellularity by an Environmentally Responsive Prion.” Cell 153, no. 1 (2013): 153–65.

Additional Reading

Halfmann, R., D. F. Jarosz. “Prions are a Common Mechanism for Phenotypic Inheritance in Wild Yeasts.” Nature 482 (2012): 363–8.

Soto, C. “Transmissible Proteins: Expanding the Prion Heresy.” Cell 149, no. 5 (2012): 968–77.

Supplemental Papers

Jones, A. K., S. D. Buckingham, et al. “Chemistry-to-Gene Screens in Caenorhabditis Elegans.” Nature Reviews Drug Discovery 4, no. 4 (2005): 321–30.

Jorgensen, E. M., and S. E. Mango. “The Art and Design of Genetic Screens: Caenorhabditis Elegans.” Nature Reviews Genetics 3, no. 5 (2002): 356–69.

Course Info

Learning Resource Types

assignment Presentation Assignments
assignment Written Assignments