Required Textbook
[GES] = 
Schneider, G. E. Brain Structure and Its Origins: In Development and in Evolution of Behavior and the Mind. MIT Press, 2014. ISBN: 9780262026734.
Supplementary Textbooks
[LWS] = Swanson, Larry W. Brain Architecture, Understanding the Basic Plan. Oxford University Press, 2011. ISBN: 9780195378580.
[JMA] = Allman, John Morgan. Evolving Brains. W. H. Freeman and Co., 1999. ISBN: 9780716750765.
Additional Supplementary Sources
[JHMF] = Nauta, Walle J. H., and Michael Feirtag. Fundamental Neuroanatomy. W. H. Freeman and Co., 1986. ISBN: 9780716717232.
[GFS] = Striedter, Georg F. Principles of Brain Evolution. Sinauer Associates, 2004. ISBN: 9780878938209.
[PB] = Brodal, Per. The Central Nervous System, Structure and Function. 3rd ed. Oxford University Press, 2003. ISBN: 9780195165609. [Preview with Google Books]
[WHAB] = Butler, Ann B., and William Hodos. Comparative Vertebrate Neuroanatomy: Evolution and Adaptation. Wiley-Liss, 1996. ISBN: 9780471888895. [Preview with Google Books]
[JWDP] = Purves, Dale, and Jeff W. Lichtman. Principles of Neural Development. Sinauer Associates, 1985. ISBN: 9780878937448.
| SES # | TOPICS & READING QUESTIONS | READINGS |
|---|---|---|
| 1–2 | Introduction: brain orientation, primitive cellular activities (PDF) | [GES] Chapters 1 and 2. |
| 3–4 | Steps to the CNS of chordates (PDF) |
[GES] Chapters 3 and 4. [GFS] Chapter 2, pp. 37–44. [JMA] Chapter 2, pp. 16–41. |
| 5–6 | Introduction to the pre-mammalian brain; specializations; overview of forebrain structures (PDF) |
[GES] Chapters 5, 6, and 7. [GFS] Chapter 3, pp. 51–81. [JHMF] Chapter 3, pp. 39–79 and Chapter 4, pp. 50–61. [LWS] Chapter 4a, pp. 40–60. |
| 7–8 | Completion of forebrain structures. CNS development and anatomy (PDF) |
[GES] Chapters 8 and 9, pp. 153–74 and Chapter 9a, pp. 175–8. [LWS] Chapter 4a, pp. 40–60. [JWDP] Chapter 1, pp. 3–23. [GFS] pp. 220–23. Figure 7.1. |
| 9–12 | Autonomic nervous system; differentiation of brain vesicles (PDF) |
[GES] Chapters 10, 11, and 12. [JHMF] Chapter 5, pp. 64–84. [JMA] Chapter 5, pp. 86–119. |
| 13–14 | CNS differentiation: Axon growth (PDF) |
[GES] Chapter 13. [JWDP] Chapter 4b, pp. 94–103 and Chapter 5, pp. 105–29. Zigmond, Michael J., Floyd E. Bloom, et al, eds. Fundamental Neuroscience. Academic Press Inc, 1999. pp. 519–46, 417–517, and 547–654. ISBN: 9780127808727. |
| 15 | Motor systems 1 (PDF) |
[GES] Chapter 14. [LWS] Chapter 6a, pp. 97–122; Chapter 5 and Chapter 6b, pp. 122–38. [JHMF] Chapter 7, pp. 91–107. [GFS] Chapter 7, pp. 217–53. |
| 16 | Motor System 2 |
[GES] Chapters 15 and 16. [LWS] Chapters 6 and 5. [JHMF] Chapter 7, pp. 91–107. [GFS] Chapter 7, pp. 217–53. |
| 17–18 | Brain states (PDF) |
[GES] Chapter 17. Much can be found using online searches. Most reliable are the papers found using Google Scholar. |
| 19 | Midterm Exam | |
| 20 |
Sheep brain dissection Please wear appropriate lab attire (i.e., long pants, close-toed shoes). |
[GES] Chapters 18 and 19. [PB] Chapter 10, pp. 233–9. Lois, Carlos, Jose-Manuel Garcia-Verdugo, et al. “Chain Migration of Neuronal Precursors.” Science 271, no. 5251 (1996): 97–81. [GFS] Chapter 5, pp. 137–57. Alvarez-Buylla, Arturo, and Jose Manuel Garcı́a-Verdugo. “Neurogenesis in Adult Subventricular Zone.” The Journal of Neuroscience 22, no. 3 (2002): 629–34. Malnic, Bettina, Junzo Hirono, et al. “Combinatorial Receptor Codes for Odors.” Cell 96, no. 5 (1999): 713–23. |
| 21–23 |
[GES] Chapters 20, 21, and 22. [JMA] Chapter 6, pp. 122–57. [GFS] Chapter 6, pp. 185–215. Figures 7.14, 7.15, and 7.16. For more advanced study by students already familiar with above: [WHAB] Chapter 18, 20, 22, 25, and 26. |
|
| 24–25 | Auditory and related sensory systems (PDF) |
[GES] Chapter 23. [JMA] Chapter 5, pp. 98–101. [GFS] Chapter 8, pp. 259–68. Figure 8.10. Chapter 5, pp. 154–7 and Chapter 5, pp. 162–71. [WHAB] Chapter 11, pp. 148–52 and Chapter 28, pp. 410–21. |
| 26 | Forebrain evolution (PDF) |
[GES] Chapter 24. [GFS] Chapter 8a, pp. 255–87. [JMA] Chapter 5. [JHMF] Chapter 13, pp. 220–38. [WHAB] Chapter 19, pp. 259–80. |
| 27–29 | Hypothalamus and limbic system, part 1 (PDF) |
[GES] Chapter 25 and 26. [JHMF] Chapter 8, pp. 108–31. [PB] Chapter 19, pp. 397–414. [LWS] Chapter 6b, pp. 117–30 and Chapter 7, pp. 194–55. Mesulam, M-Marsel, ed. Chapter 1 in Principles of Behavioral and Cognitive Neurology. Oxford University Press, 2000, pp. 64–66. ISBN: 9780195134759. [Preview with Google Books] Giesler Jr, Glenn J., James T. Katter, et al. “Direct Spinal Pathways to the Limbic System for Nociceptive Information.” Trends in Neurosciences 17, no. 6 (1994): 244–50. |
| 30 | Hormonal and other influences on brain development and plasticity (PDF) |
[GES] Chapter 27. Swaab, D. F., and M. A. Hofman. “Sexual differentiation of the human hypothalamus in relation to gender and sexual orientation.” Trends in Neurosciences 18, no. 6 (1995): 264–70. Nottebohm, Fernando. “From Bird Song to Neurogenesis.” Scientific American 260, no. 2 (1989): 74–9. Kimura, Doreen. “Sex Differences in the Brain.” Scientific American 267, no. 3 (1992): 118–25. Zigmond, Michael J., Floyd E. Bloom, et al, eds. Fundamental Neuroscience. Academic Press Inc, 1999. ISBN: 9780127808727. Chapter 47, pp. 1229–44, box 47.2 and box 47.3. |
| 31 | Hippocampal formation (PDF) |
[GES] Chapter 27. [GFS] Chapter 5, pp. 171–6 and Chapter 8, pp. 290–94. [PB] Chapter 30, section on Evolutionary perspective (to get a flavor of the comparative work). Mesulam, M-Marsel, ed. Chapter 1 in Principles of Behavioral and Cognitive Neurology. Oxford University Press, 2000, pp. 1–120, and 49–64. ISBN: 9780195134759. [Preview with Google Books] |
| 32 | Amygdala and other aspects of limbic forebrain (PDF) |
[GES] Chapter 29. [PB] Chapter 20, pp. 415–34. Mesulam, M-Marsel, ed. Chapter 1 in Principles of Behavioral and Cognitive Neurology. Oxford University Press, 2000, pp. 1–120, and 49–64. ISBN: 9780195134759. [Preview with Google Books] |
| 33–34 | Corpus striatum (PDF) |
[GES] Chapters 30 and 31. Chapter 31, Intermission. [JHMF] pp. 99, figure 48. pp. 97–101. [GFS] Chapter 8, pp. 287–9 and Chapter 8. [PB] Chapter 13, pp. 286–302. Mesulam, M-Marsel, ed. Chapter 1 in Principles of Behavioral and Cognitive Neurology. 2nd ed. Oxford University Press, 2000, pp. 66–71. ISBN: 9780195134759. [Preview with Google Books] |
| 35–37 |
[GES] Chapter 32 (chapter 32 contains a number of novel proposals about how the hemispheres function. It is important for students to read this, especially because it will not all be covered in lectures.); Chapter 33 and Chapter 34. [JMA] Chapter 7, pp. 160–208. [JHMF] Chapter 13, pp. 220–27 and 235–38 (concerning the skipped passages: do study all the figures and figure legends). Chapter 16, pp. 289–307. [PB] Chapter 21, pp. 435–64 (Through p 446 is basic; remainder is on association cortex. Some of this is redundant, but that helps! Key points from Nauta and Brodal will be covered in class). [JWDP] Chapter 4, pp. 91–5. Rakic, Pasko. “A small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolution.” Trends in Neurosciences 18, no. 9 (1995): 383–88. For more advanced reading: [GFS] Chapter 9, pp. 297–344. Mesulam, M-Marsel, ed. Chapter 1 in Principles of Behavioral and Cognitive Neurology. 2nd ed. Oxford University Press, 2000, pp. 1–17, 21–54, and 71–75. ISBN: 9780195134759. [Preview with Google Books] Finlay, Barbara L., and Richard B. Darlington. “Linked Regularities in the Development and Evolution of Mammalian Brains.” Science 268, no. 5217 (1995): 1578–84. Bonhoeffer, Tobias. “Neurotrophins and Activity-dependent Development of the Neocortex.” Current Opinion in Neurobiology 6, no. 1 (1996): 119–26. Sur, Mriganka, Alessandra Angelucci, et al. “Rewiring Cortex: The Role of Patterned Activity in Development and Plasticity of Neocortical Circuits.” Journal of Neurobiology 41, no. 1 (1999): 33–43. Bai, Wanzhu, Mami Ishida, et al. “Role of the Protomap and Target-derived Signals in the Development of Intrahemispheric Connections.” Cerebral Cortex 16, no. 1 (2006): 124–35. For supplemental reading on Nauta: [JHMF] Chapter 13, pp. 220–27 and 235–38 and Chapter 16, pp. 289–307. |
|
| 38 | Plasticity in brain connections; Review (PDF) | [GES] Chapter 34. |
| Final Exam |
Additional Recommended Readings
There are a number of additional recommended readings for this course.
