D-Lab: Medical Technologies for the Developing World

Labs and Readings

LAB #	TOPICS	READINGS
1	Drug delivery	Mizrahi, Boaz, and Abraham J. Domb. “Mucoadhesive Tablet Releasing Iodine for Treating Oral Infections.” Journal of Pharmaceutical Sciences 96, no. 11 (2007): 3144-50. Shemer, Avner, et al. “Efficacy of a Mucoadhesive Patch Compared with an Oral Solution for Treatment of Aphthous Stomatitis.” Drugs in R&D 9, no. 1 (2008): 29-35.
2	Diagnostics	Chin, Curtis D., Vincent Linder, and Samuel K. Sia. “Lab-on-a-Chip Devices for Global Health: Past Studies and Future Opportunities.” Lab Chip 7, no. 1 (2007): 41-57. Yuen, Po Ki, and Vasiliy N. Goral. “Low-Cost Rapid Prototyping of Flexible Microfluidic Devices Using a Desktop Digital Craft Cutter.” Lab Chip 10, no. 3 (2010): 384-7. Kaigala, Govind V., et al. “Rapid Prototyping of Microfluidic Devices with a Wax Printer.” Lab Chip 7, no. 3 (2007): 384-7. Martinez, Andres W., Scott T. Phillips, and George M. Whitesides. “Three-dimensional Microfluidic Services Fabricated in Layered Paper and Tape.” Proceedings of the National Academy of Sciences 105, no. 50 (2008): 19606-11. Paper diagnostics Combur-10 test: Combur-Test® Product Line. Roche Diagnotics. Accessed December 20, 2010. Grifantini, Kristina. “TR10: Paper Diagnostics.” Technology Review, March/April 2009. Urdea, Mickey, et al. “Requirements for High Impact Diagnostics in the Developing World.” Nature (published online November 22, 2006): 73-9.
3	Instrumentation
4	Vital signs monitoring
5	Microfluidics	Schilling, Eric, and Paul Yager. “Basic Microfluidic Concepts.” September 7, 2001. Accessed August 25, 2009. Goho, Alexandra. “Diagnosing the Developing World: Turning High-tech Innovations into Low-cost Medical Tests.” Science News, February 14, 2004. Sia, Samuel K., and Larry J. Kricka. “Microfluidics and Point-of-Care Testing.” Lab Chip 8, no. 12 (2008): 1982-3. Sia, Samuel K., and George M. Whitesides. “Microfluidic Devices Fabricated in Poly(dimethylsiloxane) for Biological Studies.” Electrophoresis 24, no. 21 (2003): 3563-76. U.S. CDC and WHO. “Overview of HIV Testing Technologies (PDF).” Module 3 in HIV Rapid Testing Training Package, Participant Manual, 2005.
6	Visit to Shriners Hospital for Children, Boston, MA
7-13	Project team work