EC.710 | Spring 2010 | Undergraduate

D-Lab: Medical Technologies for the Developing World

Lectures and Readings

Part I: Survey of global health challenges and medical device categories
1 Introduction, global health overview Slides (PDF - 2.4MB)  
2 Drug delivery overview Jose Gomez-Marquez. “D-Lab Health: Drug Delivery Prototypes.” February 16, 2010. Accessed October 8, 2010. These prototypes were built during Lab 1: Drug delivery.

Hingson, Robert A. “The Development of the Hypospray for Parenteral Therapy by Jet Injection.” Anesthesiology 10, no. 1 (1949): 66-75. [PDF available for download]

Towle, Richard L. “New Horizon in Mass Inoculation.” Public Health Reports 75, no. 6 (1960): 471-6.

Vaccination By Jet.” The British Medical Journal 2, no. 5530 (1966): 1610.

Hernandez, Marita. “Hepatitis Cases Blamed on Clinic’s Use of ‘Jet Gun’.” Los Angeles Times, October 8, 1985.

Anahtar, Melis N. “Needle-Free Injectors as a Sustainable Alternative to Syringes.” MIT International Review, Spring 2008.

View product information for the PharmaJet® device.

See inspiration for the jet injector: MarauderFaerie. “Hypospray Examples.” November 3, 2009. YouTube. Accessed October 5, 2010.

For background on the inspiration for the jet injector, see: Williams, Horatio B. “Hazard of Diesel Engine Oil Under Pressure.” Journal of the American Medical Association 117, no. 5 (1941): 386.

Flinn, Edward D. “Ouch-less Injections.” Popular Science, October 1998. [Read in Google Books]

3 Infectious diseases Slides (PDF - 3.5MB)  
4 Non-communicable diseases  

Disease Control Priorities Project. Disease Control Priorities in Developing Countries [abstracts, PDF and full text HTML available for download]
- Chapter 30, “Diabetes: The Pandemic and Potential Solutions.” by K. M. Venkat Narayan, et al.
- Chapter 33, “Cardiovascular Disease.” by Thomas A. Gaziano, et al.

International Atomic Energy Agency. A Silent Crisis: Cancer Treatment in Developing Countries. September 2003. (PDF)

McNeil Jr., Donald G. “In India, a Quest to Ease the Pain of the Dying.” New York Times, September 11, 2007.

———. “Procedure May Save Women In Third World From Cancer.” New York Times, March 25, 2003.

Monroy-Hernandez, Andres, and Leo Anthony Celi, MD. “ICT4D to Scale Cervical Cancer Prevention.” May 07, 2008. YouTube. Accessed August 25, 2009.

5 Capturing heart and lung sounds on a mobile phone – guest lecture by Katherine Kuan Slides (PDF - 1.4MB). Courtesy of Katherine Kuan.  
6 Advances in telemedicine and patient monitoring Slides (PDF). Courtesy of Gari Clifford. Presentation from Spring 2009 edition of D-Lab Health.

Martinez, Andres W., et al. “Simple Telemedicine for Developing Regions: Camera Phones and Paper-Based Microfluidic Devices for Real-Time, Off-Site Diagnosis.” Analytical Chemistry 80 (2008): 3699-707.

Szot, Agneiszka, et al. “Diagnostic Accuracy of Chest X-rays Acquired Using a Digital Camera for Low-cost Teleradiology.” International Journal of Medical Informatics 73 (2004): 65-73. (PDF)

amithap1982. “CytoSight a Telepathology Solution by KTwo powered by Intel.” February 4, 2009. YouTube. Accessed August 25, 2009.

Gomez-Marquez, Jose. “The Challenges of Teaching and Learning Creativity.” Supplemental reading for D-Lab Health, 2010. (PDF)

Zoomify Enterprise - a telepathology software interface.

7 Vaccines Slides (PDF - 1.1MB)

Kahn, Jonathan. “Race in a Bottle.” Scientific American, August 2007.

Wuethrich, Bernice, ed. “Introduction and Sustainable Use of Vaccines in Developing Countries.” Proceedings of the Albert B. Sabin Vaccine Institute 12th Annual Vaccine Policy Colloquium, October 19-21, 2005. 

Students Devise Oral Quick-Dissolve Strips for Rotavirus Vaccine.” Johns Hopkins University press release, May 14, 2007.

Mullins, Justin. “Immune System in a Jar.” New Scientist: Invention Blog, March 05, 2008.

Groleau, Rick. “Killer Disease on Campus: Making Vaccines.” PBS: NOVA, August 2002.

Mitragotri, Samir. “Immunization without Needles.” Nature Reviews Immunology 5 (December 2005): 905-16.

Garcia-Contreras, Lucila, et al. “Immunization by a Bacterial Aerosol.” Proceedings of the National Academy of Sciences 105, no. 12 (2008): 4656-60.

Flatow, Ira, and Alex Chadwick. “Vaccine Tech Could Help Millions in Developing Nations.” National Public Radio, October 21, 2004.

Chowdury, Zafrin. “Bangladesh Launches Mass Immunization Campaign after Polio Re-emerges.” UNICEF, 2006. Associated video (RM - 36K) (RM - 458K).

8 Arduous Arduino – guest lecture by Paul Hlebowitsh Slides (PDF - 1.8MB). Courtesy of Paul Hlebowitsh. Used with permission.  
Week #8: Spring break, Nicaragua trip
Part II: Project design and development
9 User and setting-driven innovations to advance global healthcare– guest lecture by Kris Olson  

Design that Matters Incubator Article Archive, including photos, text and videos

byronetics. “Aravind Eye Hospital.” November 19, 2006. YouTube. Accessed August 25, 2009.

10 Prototyping of medical devices   Professor Focused on Cheap Specs.” BBC News, February 9, 2009.
11 Neglected tropical diseases Slides (PDF - 1.5MB)

Enserink, Martin. “Some Neglected Diseases Are More Neglected Than Others.” Science 323, no. 5915 (2009): 700.

Yager, Paul, Gonzalo J. Domingo, and John Gerdes. “Point-of-Care Diagnostics for Global Health.” A_nnual Review of Biomedical Engineering_ 10 (2008): 107-44.

Moran, Mary et al. “Neglected Disease Research and Development: How Much Are We Really Spending?” PLoS Medicine 6, no. 2 (2009). (PDF - 1.1MB)

12 Disabilities in the developing world   Norton, Quinn. “Give ’em a (Working) Hand.” Wired, September 21, 2006.
13 Project team formation    
14 FDA approvals    
15 Project brainstorming    
16 Visit to MIT laser cutter and 3-D printer    
17 Project team work    
18 Project team work    
19 Project team work    
20 Project team work    
21 Project team work    
22 Project team work    
23 Role-playing simulation games    
24 Project team work, sketch model review feedback    
25 Project team work    
26 Project wrap-up    

Supplemental Readings

Supporting material for the course textbook (Rx for Survival)

Geelhoed, Glenn W. Surgery and Healing in the Developing World. (PDF - 4.71MB) Georgetown, TX: Landes Biosciences, 2005. [a complete online text]

Werner, David, Carol Thurman, and Jane Maxwell. Where There Is No Doctor: A Village Health Care Handbook. Updated. 2nd ed. Berkely, CA: Hesperian Foundation, 1992. ISBN: 9780942364156.

Gordon, Bruce, Richard Mackay, and Evan Rehfuess. Inheriting the world: The Atlas of Children’s Health and the Environment. Geneva, Switzerland: WHO, 2004. ISBN: 9789241591560.

BIO Ventures for Global Health (BVGH). “Global Health Primer.”

  • A tremendous resource on diseases that form the focus in global health: background information, descriptive “disease sheets”, lists of organizations, NGOs, advocacy groups, biotech companies and other partnerships, all engaged in trying to address these problems.

Google Flu Trends

Helft, Miguel. “Google Uses Searches to Track Flu’s Spread.” New York Times, November 11, 2008.

Medical Hacks: DIY projects with step by step instructions.

Fountain, Henry. “Managing Disasters With Small Steps.” New York Times, January 18, 2010.

Potential Encapsulated: Medicines that can Talk to Doctors Herald a New Direction for Drugs Firms.” The Economist, January 14, 2010.

Course Info

As Taught In
Spring 2010
Learning Resource Types
Design Assignments with Examples