Instructor key:
[MBY] = Prof. Michael B. Yaffe
[MVH] = Prof. Matthew Vander Heiden
| lec # | topic | instructor | key dates |
|---|---|---|---|
|
Part I: Biomolecules, Methods, and Mechanisms |
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|
1 |
Introduction; Classes of Biomolecules; pH, Buffers, and Titration Curves | MBY | Problem set 1 assigned |
|
2 |
Amino Acids and Proteins | MBY | |
| 3 | Protein Purification I | MBY |
Problem set 1 due Problem set 2 assigned |
|
4 |
Protein Purification II, Protein Structure II | MBY | |
|
5 |
Protein Structure II, Protein Folding | MBY | |
| 6 | Hemoglobin and Allostery | MBY |
Problem set 2 due Problem set 3 assigned |
|
7 |
Hemoglobin and the Bohr Effect | MBY | |
|
8 |
Enzyme Chemistry | MBY | |
| 9 | Enzymes as Catalysts | MBY |
Problem set 3 due Problem set 4 assigned |
|
10 |
Enzyme Mechanisms | MBY | |
|
11 |
Enzyme Kinetics | MBY | Problem set 4 due |
|
Exam 1: Focus on Lectures 1–10 |
Problem set 5 assigned | ||
|
12 |
Carbohydrates/Introduction to Membranes | MVH | |
|
13 |
Channels, Transporters and Pumps, Protein Modules | MBY | |
| 14 | Hormones and Signal Transduction I | MBY |
Problem set 5 due Problem set 6 assigned |
|
15 |
Receptors, Small G-proteins, and Signal Transduction II | MBY | |
|
16 |
Nucleic Acids | MBY | |
|
17 |
tRNAs and Protein Translation | MBY | Problem set 7 assigned |
|
18 |
Translation and the Ribosome | MBY | Problem set 6 due |
|
Exam 2: Focus on Lectures 11–16 |
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|
Part II: Metabolism |
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|
19 |
Introduction to Metabolism/Polysaccharides/Bioenergetics/Intro Pathways | MVH | |
|
20 |
Bioenergetics/Intro Pathways/Glycolysis I | MVH | |
| 21 | Glycolysis II/Regulation | MVH |
Problem set 7 due Problem set 8 assigned |
|
22 |
Glucogenesis/Carbohydrate Storage/TCA Cycle I | MVH | |
|
23 |
TCA Cycle II | MVH | |
| 24 | Lipids and Fatty Acid Oxidation | MVH |
Problem set 8 due Problem set 9 assigned |
|
Exam 3: Focus on Lectures 17–23 |
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|
25 |
Oxidative Phosphorylation | MVH | Problem set 10 assigned |
|
26 |
Oxidative Phosphorylation/Photosynthesis I | MVH |
Problem set 9 due |
|
27 |
Photosynthesis II/CO2 Assimilation | MVH | |
| 28 | Pentose Phosphate Pathway | MVH |
Problem set 10 due Problem set 11 assigned |
|
29 |
Lipid Synthesis | MVH | |
|
30 |
Nitrogen/Amino Acid Metabolism I | MVH | |
|
31 |
Amino Acid Metabolism II | MVH | Problem set 11 due |
|
32 |
Nucleotide Metabolism | MVH | |
|
Exam 4: Focus on lectures 24–32 |
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