7.05 | Spring 2020 | Undergraduate

General Biochemistry


Optional Readings

Additional textbooks that may be helpful for specific topics:

Campbell, Iain D. Biophysical Techniques. Oxford: Oxford University Press, 2012. ISBN: 9780199642144

This book has an excellent discussion of many currently used techniques to characterize macromolecules. It is a very useful text for those of you who are doing (or plan to do) biochemical research.

Branden, Carl, and John Tooze. Introduction to Protein Structure, 2nd ed. New York: Garland Publishing, 2009. ISBN: 9780815323051

Provides an elegant description of a variety of protein structures, including many of the proteins we discuss in class such as G-proteins, proteases, and nucleic acid-binding proteins. Use this book if you want to get a different, somewhat better understanding of the structural basis for how these proteins work than that provided in the Stryer textbook. Carl Branden is the inventor of the so-called “Branden Rules” that allow ligand binding sites to be predicted in α/β proteins by looking at the α-helix cross-over positions on the β-sheet, and places in the sheet where the order of β-strands reverses itself.

Rhodes, Gale. Crystallography Made Crystal Clear: A Guide for Users of Macromolecular Models, 3rd ed. Academic Press, 2006. ISBN: 9780125870733

This is an outstanding introduction to how protein structures are solved using crystallography. If the handwaving explanation of the phase problem that I provide in class is not satisfying enough for you, and you really want to understand how Fourier transforms are used to solve X-ray structures, this is the book for you.

Tanford, Charles, and Jacqueline A. Reynolds. Nature’s Robots: A History of Proteins. Oxford University Press, 2004. ISBN: 9780198606949

This is a classic book on the history of protein discovery and characterization, written by a pioneer in the field of biophysical chemistry. Prof. Tanford is also the author of two classic textbooks in chemistry and biochemistry, and he has a very unique and deep knowledge of the field. If you are a fan of the history of science, this is the kind of book you take on vacation to read for fun.

Course Info

As Taught In
Spring 2020
Learning Resource Types
Lecture Videos
Problem Sets with Solutions