Readings are from Berg, Tymockzko, Gatto, and Stryer Biochemistry (8th Edition) OR from Miesfeld & McEvoy Biochemistry. Read one or the other. There is no need to read both.
[BTGS] = Berg, Jeremy M., John L. Tymoczko, Gregory J. Gatto, and Lubert Stryer. Biochemistry. 8th ed. W. H. Freeman & Co., 2015. ISBN: 9781464126109.
[MM] = Miesfeld, Roger L., and Megan M. McEvoy. Biochemistry. W. W. Norton & Company, 2017. ISBN: 9780393614022.
| lec # | topic | readings | |
|---|---|---|---|
| Part I: Biomolecules, Methods, and Mechanisms (Lectures by Prof. Michael B. Yaffe) | |||
| 1 | Introduction; Classes of Biomolecules; pH, Buffers, and Titration Curves |
[BTGS] pp. 1–4, 13–17, 22–23 (Appendix 1) or [MM] pp. 3–17, 56–60, 71–78 |
|
| 2 | Amino Acids and Proteins |
[BTGS] pp. 27–39, 57–59 or [MM] pp. 11–12, 147–168 |
|
| 3 | Protein Purification I |
[BTGS] pp. 65–84, 92–95 or [MM] pp. 210–226 |
|
| 4 | Protein Purification II, Protein Structure II |
[BTGS] pp. 35–49, 59–62, 85–92 or [MM] pp. 162–193, 227–230 |
|
| 5 | Protein Structure II, Protein Folding |
[BTGS] pp. 6–9, 44–60, 169–182 or [MM] pp. 56–67, 193–204, 232–237 |
|
| 6 | Hemoglobin and Allostery |
[BTGS] pp. 191–212, 286–292, 356–358 or [MM] pp. 259–276 |
|
| 7 | Hemoglobin and the Bohr Effect |
[BTGS] pp. 191–212 or [MM] pp. 259–276 |
|
| 8 | Enzyme Chemistry |
[BTGS] pp. 215–218, 237–238, 251–264 or [MM] pp. 309–319, 332–336 |
|
| 9 | Enzymes as Catalysts |
[BTGS] pp. 219–225, 240–241, 299–303 or [MM] pp. 3319–332, 362–363 |
|
| 10 | Enzyme Mechanisms |
[BTGS] pp. 264–268 (Carbonic Anhydrase), 455–456 (TPI) or [MM] pp. 326–327 (Carbonic Znhydrase), 455–457 (TPI) |
|
| 11 | Enzyme Kinetics |
[BTGS] pp. 225–236 or [MM] pp. 341–356 |
|
| 12 |
Carbohydrates/Introduction to Membranes (Lecture by Prof. Matthew Vander Heiden) |
[BTGS] pp. 313–337 or [MM] pp. 632–672 |
|
| 13 | Channels, Transporters and Pumps, Protein Modules |
[BTGS] pp. 367–393 or [MM] pp. 276–295 |
|
| 14 | Hormones and Signal Transduction I |
[BTGS] pp. 293–298, 397–419 or [MM] pp. 359–360, 371–397 |
|
| 15 | Receptors, Small G-proteins, and Signal Transduction II |
[BTGS] pp. 367–393, 397–419 or [MM] pp. 255–256, 276–295, 383–385, 397–415 |
|
| 16 | Nucleic Acids |
[BTGS] pp. 4–6, 105–118 or [MM] pp. 23–27, 91–101, 107–115 |
|
| 17 | tRNAs and Protein Translation |
[BTGS] pp. 827–844, 941–944, 119–123, 859–880, 925–931, 945–947 or [MM] pp. 999–1009, 1010–1021, 1065–1071, 1077–1098 |
|
| 18 | Translation and the Ribosome |
[BTGS] pp. 876–890 or [MM] pp. 1055–1061, 1074–1086 |
|
| Part II: Metabolism (Lectures by Prof. Matthew Vander Heiden) | |||
| 19 | Introduction to Metabolism/Polysaccharides/Bioenergetics/Intro Pathways |
[BTGS] Ch. 11.1-11.2, 15, 16.1-16.3, 21 or [MM] Ch. 9, 14.2-14.3 |
|
| 20 | Bioenergetics/Intro Pathways/Glycolysis I |
[BTGS] Ch. 17 or [MM] Ch. 10 |
|
| 21 | Glycolysis II/Regulation |
[BTGS] Ch. 17 or [MM] Ch. 10 |
|
| 22 | Glucogenesis/Carbohydrate Storage/TCA Cycle I |
[BTGS] Ch. 11.1-11.2, 15, 17, 16.1-16.3, 21 or [MM] Ch. 9, 10, 14.2-14.3 |
|
| 23 | TCA Cycle II |
[BTGS] Ch. 17 or [MM] Ch. 10 |
|
| 24 | Lipids and Fatty Acid Oxidation |
[BTGS] Ch. 12.1–12.5, 18, 19, 22 or [MM] Ch. 11, 12, 15.1–15.3, 16.1 |
|
| 25 | Oxidative Phosphorylation |
[BTGS] Ch.12.1–12.5, 18, 19, 22 or [MM] Ch. 11, 12, 15.1–15.3, 16.1 |
|
| 26 | Oxidative Phosphorylation/Photosynthesis I |
[BTGS] Ch. 12.1–12.5, 18, 19, 22 or [MM] Ch. 11, 12, 15.1–15.3, 16.1 |
|
| 27 | Photosynthesis II/CO2 Assimilation |
[BTGS] Ch. 12.1–12.5, 18, 19, 20.1–20.2, 22 or [MM] Ch. 11, 12, 15.1–15.3, 16.1 |
|
| 28 | Pentose Phosphate Pathway |
[BTGS] Ch. 19, 20 or [MM] Ch. 14.1 |
|
| 29 | Lipid Synthesis |
[BTGS] Ch. 20.3–20.5, 22.4–22.6 or [MM] Ch. 16.2 |
|
| 30 | Nitrogen/Amino Acid Metabolism I |
[BTGS] Ch. 23.3–23.5, 24 or [MM] Ch. 17 |
|
| 31 | Amino Acid Metabolism II |
[BTGS] Ch. 23.3–23.5, 24 or [MM] Ch. 17 |
|
| 32 | Nucleotide Metabolism |
[BTGS] Ch. 25 or [MM] Ch. 18 |
|
