20.310J | Spring 2015 | Undergraduate

Molecular, Cellular, and Tissue Biomechanics

Lecture Slides

Instructor Key

RK = Roger Kamm
AG = Alan Grodzinsky

LEC # TOPICS & SLIDES INSTRUCTORS
Molecular Mechanics
1

Length, Time, & Molecular-scale Forces in Biology (PDF - 1.6MB)

RK
2

Single Molecule Mechanics (PDF)

RK
3

Energy Landscapes and Transition States (PDF)

RK
4

Mechanochemistry at the Molecular Scale (PDF - 3.7MB)

AG
5

Kramers’ and Bell’s Models of Reversible Binding (PDF - 1.3MB)

RK
6

Experimental Methods in Single Molecule Mechanics (PDF - 1.5MB)

RK
Tissue Mechanics
7

Composition of Extracellular Matrix Constituents of Tissues; Relevance to Elastic (Time-independent) Behavior of Tissues (PDF - 2.8MB)

AG
8

Elastic (Time-independent) Behavior of Tissues (cont.) (PDF - 2.1MB)

AG
9

Elastic (Time-independent) Behavior of Tissues (cont.) (PDF - 2.2MB)

AG
Time-dependent Tissue Behavior (Viscoelasticity and Poroelasticity)
10

Finish Topics on Tissue Elasticity; Begin Viscoelasticity (PDF - 1.8MB)

AG
11

Time-dependent Viscoelasticity of Tissues (PDF - 2.2MB)

AG
12

Dynamic (Frequency-dependent) Viscoelasticity (PDF - 1.7MB)

AG
13

Poroelastic (Time-dependent) Behavior of Tissues (PDF - 2.3MB)

AG
14

Poroelastic (Frequency-dependent) Behavior of Tissues (PDF - 1.8MB)

AG
15

Dynamic Nanomechanical Behavior of Extracellular Matrix Macromolecules (PDF - 3.1MB)

AG
16

Time- and Frequency-dependent Behavior of Intracellular Networks (PDF - 2.7MB)

AG
Cell Mechanics
17

Cell Mechanics: Structure of the Cell (PDF - 1.8MB)

RK
18

Visco / Poroelasticity, Large Amplitude Deformations (PDF)

RK
19

Microstructural Models of the Cytoskeleton (PDF)

RK
20

The Cell Membrane (PDF)

RK
21

Cell Motility and Mechanotransduction (PDF - 1.3MB)

RK
Capstone Problems
22

The Physics of Cancer (PDF - 3.4MB)

RK
  Term Project Group Presentations  
  Term Project Group Presentations (cont.)  
23

Molecular Electromechanics: Electromechanical and Physicochemical Properties of Tissues (Lecture Slides are not available.)

AG
24 Muscle from the Molecular, Cellular and Tissue Perspectives (Lecture Slides are not available.) RK