Designing and Sustaining Technology Innovation for Global Health Practice

Readings

LEC #	TOPICS	READINGS
1	Overview	Chapters in Disease Control Priorities in Developing Countries (DCP). 2nd ed. World Bank, 2006. Jamison, D. T. Chapter 1, “Investing in Health.” Laxminarayan, R., J. Chow, and S. A. Shahid-Salles. Chapter 2, “Intervention Cost-Effectiveness: Overview of Main Messages.” Bloom, B. R., C. M. Michaud, J. R. Montagne, and L. Simonsen. Chapter 4, “Priorities for Global Research and Development of Interventions.” Dees, J. G. “The Meaning of ‘Social Entrepreneurship.’” (2001). (PDF) Drayton, B. “Everyone a Changemaker: Social Entrepreneurship’s Ultimate Goal.” Innovations 1, no. 1 (Winter 2006): 80-96. (PDF - 5.5 MB) Garrett, L. “The Challenge of Global Health.” Foreign Affairs 86, no. 1 (February 2007): 14-38. (PDF) United Nations. “Millenium Development Goals Report.” Varmus, H., et al. “Grand Challenges in Global Health.” Science 302 (October 17, 2003): 398-399. Wood, A., and M. Martin. “Market-Based Solutions for Financing Philanthropy.” UBS Philanthropy Services, 2006. (PDF)
2	Expanding global access to life saving vaccines: HPV vaccine case study	Infectious Diseases (ID) World Health Organization (WHO). “Global Health: Today’s Challenges.” Chapter 1 in The World Health Report 2003 — Shaping the Future. United Republic of Tanzania. Annual Health Statistical Abstract, 2006. Chapters in Disease Control Priorities in Developing Countries (DCP). 2nd ed. World Bank, 2006. Dye, C., and K. Floyd. Chapter 16, “Tuberculosis.” Bertozzi, S., et al. Chapter 18, “HIV/AIDS Prevention and Treatment.” Brenzel, L, et al. Chapter 20, “Vaccine-preventable Diseases.” Breman, J. G., et al. Chapter 21, “Conquering Malaria.” Biotech innovation BIO Ventures for Global Health (BVGH). “Global Health Primer.” October 2007. (PDF) ———. “Closing the Global Health Innovation Gap: A Role for the Biotechnology Industry in Drug Discovery for Neglected Diseases.” November 2007.  HPV vaccines World Health Organization. “Assessing New Vaccines for National Immunization Programmes: A Framework to Assist Decision Makers.” 2000. (PDF) Kane, M. A., et al. “Chapter 15: HPV Vaccine Use in the Developing World.” Vaccine 24 Supplement 3 (2006): S3/132-S3/139. Goldie, S. J., J. J. Kim, and E. Myers. “Chapter 19: Cost-effectiveness of Cervical Cancer Screening.” Vaccine 24 Supplement 3 (2006): S3/164-S3/170. Sherris, J., et al. “Chapter 25: Education, Training, and Communication for HPV Vaccines.” Vaccine 24 Supplement 3 (2006): S3/210-S3/218.
3	New systems for drug delivery	Noncommunicable Disease (NCD) Chapters in Disease Control Priorities in Developing Countries (DCP). 2nd ed. World Bank, 2006. Simoes, E. A. F., et al. Chapter 25, “Acute Respiratory Infections in Children.” Brown, M. L., et al. Chapter 29, “Health Service Interventions for Cancer Control in Developing Countries.” Venkat Narayan, K. M., et al. Chapter 30, “Diabetes: The Pandemic and Potential Solutions.” Gaziano, T. A. Chapter 33, “Cardiovascular Disease.” Muhimbili National Hospital, Tanzania. “Business Plan for Cardiac Care Unit.” Drug delivery Hopkins, A. L., M. J. Witty, and S. Nwaka. “Mission Impossible.” Nature 449 (September 13, 2007): 166-169. Technology innovation Betz, F. “Technology and Society,” and “New High-Tech Businesses.” Chapters 1 and 10 in Managing Technology Innovation. New York, NY: Wiley-IEEE, 1998. ISBN: 9780471225638. (Preview this book in Google Books.) Systems and HRH Mills, A., F. Rasheed, and S. Tollman. “Strengthening Health Systems.” Chapter 3 in Disease Control Priorities in Developing Countries (DCP). 2nd ed. World Bank, 2006. Zanzibar Ministry of Health and Social Welfare. “Human Resource for Health 5-year Development Plan, 2004/05-2008/09” (Final Draft). Tanzania Ministry of Health and Social Welfare. “Strategic Human Resources Plan (Draft 1),” April 2006. Mæstad, Ottar. “Human Resources for Health in Tanzania: Challenges, Policy Options and Knowledge Gaps.” Bergen, Norway: Chr. Michelsen Institute Report R 2006: 3.
4	Microfluidics and global health practice	Microfluidics Ozcan, A., and U. Demirci. “Ultra Wide-field lens-free Monitoring of Cells On-chip.” Lab Chip 8 (2008): 98-106. doi:10.1039/b713695a. Rodriguez W. R., N. Christodoulides, P. N. Floriano, S. Graham, and S. Mohanty, et al. “A Microchip CD4 Counting Method for HIV Monitoring in Resource-Poor Settings.” PLoS Medicine 2, no. 7, e182 (July 2005): 663-672. doi:10.1371/journal.pmed.0020182. Chin, C., V. Linder, and S. K. Sia. “Lab-on-a-Chip Devices for Global Health: Past Studies and Future Opportunities.” Lab Chip 7 (2007): 41-57. doi:10.1039/b611455e. Yager, P., et al. “Microfluidic Diagnostic Technologies for Global Public Health.” Nature 442 (July 27, 2006): 412-418. doi:10.1038/nature05064. Antia M., T. Herricks, and P. K. Rathod. “Microfluidic Modeling of Cell—Cell Interactions in Malaria Pathogenesis.” PLoS Pathogens 3, no. 7, e99 (2007). doi:10.1371/journal.ppat.0030099. Social business Yunus, M. “A New Kind of Business,” and “Social Business.” Chapters 1 and 2 in Creating a World Without Poverty. Cambridge, MA: PublicAffairs, 2009. ISBN: 9781586486679. Oster, S. M., et al., eds. Chapters in Generating and Sustaining Nonprofit Earned Income. New York, NY: Jossey-Bass, 2004. ISBN: 9780787972387. Dees, J. G. Chapter 1, “Putting Nonprofit Business Ventures in Perspective.” Davis, L., and N. Etchart. Chapter 12, “Supporting Nonprofit Enterprise in Emerging Markets.”
5	Alternative energy sources	Svoboda, E. “Fueling the Future: The Oil Well of Tomorrow may be in a California Lab Full of Genetically Modified, Diesel-spewing Bacteria.” Fast Company 122 (2008) [A profile of company LS9.] O’Neil, T., and E. Kashi. “The Curse of the Black Gold: Hope and Betrayal in the Niger Delta.” National Geographic, February 2007. Hammond, Allen L., et al. “The Energy Market.” Chapter 7 in The Next 4 Billion: Market Size and Business Strategy at the Base of the Pyramid. Washington, DC: World Resources Institute, 2007. von Schirnding, Y., et al., ed. “Addressing the Impact of Household Energy and Indoor Air Pollution on the Health of the Poor: Implications for Policy Action and Intervention Measures.” World Health Organization, 2002. (PDF) Warwick, H., and A. Doig. “Smoke — The Killer in the Kitchen: Addressing Indoor Air Pollution in Developing Countries.” ITDG Publishing, 2004. (PDF 4.6 MB)
6	R&D for resource poor settings	Webber, D., and M. Kremer. “Perspectives on Stimulating Industrial Research and Development for Neglected Infectious Diseases.” Bulletin of the World Health Organization 79, no. 8 (2001): 735-741. Chokshi, D. A., and R. Rajkumar. “Leveraging University Research to Advance Global Health.” JAMA 298, no. 16 (October 24/31, 2007): 1934-1936. McCannon, C. J., D. M. Berwick, and M. R. Massoud. “The Science of Large-Scale Change in Global Health.” JAMA 298, no. 16 (October 24/31, 2007): 1937-1939. Tanzania, “National Health Policy.” 1990 (PDF - 2.4 MB) Tanzania, “The National Science and Technology Policy for Tanzania.” 1996 (PDF - 2.4 MB) “Growing out of Poverty.” Tanzania Poverty Monitoring System (NSGRP aka MKUKUTA), 2005. (PDF - 1.3MB)
7	Field trip to BAMM laboratory	Prof. Demirci’s BAMM Labs
8	Medical device development	Norton, Q. “Give ’em a (Working) Hand.” Wired, September 21, 2006. Geelhoed, G. Surgery and Healing in the Developing World. (PDF - 4.7MB) Austin, TX: Landes Biosciences, 2005. McGirk, T. “The $28 Foot.” Time, October 1, 1997. Phillips, R. “Everything You Ever Wanted to Know about Medical Device Marketing Clearance.” Center for Devices and Radiological Health, U. S. Food and Drug Administration. (PDF) Hammond, Allen L., et al. “The Health Market.” Chapter 2 in The Next 4 Billion: Market Size and Business Strategy at the Base of the Pyramid. Washington, DC: World Resources Institute, 2007. Paul, J. “Development without the Dependency.” NextBillion.net, 2006. World Health Organization. “Medical Devices and Equipment.”
9	Electronic medical records and research systems	Fraser, H. S. F., et al. “Implementing Electronic Medical Record Systems in Developing Countries.” Informatics in Primary Care 13 (2005): 83-95. Hannan, T. J., et al. “The Mosoriot Medical Record System: Design and Initial Implementation of an Outpatient Electronic Record System in Rural Kenya.” International Journal of Medical Informatics 60 (2000): 21-28. Chaulagai, C. N., et al. “Design and Implementation of a Health Management Information System in Malawi.” Health Policy and Planning 20, no. 6 (November 2005): 375-84. (PDF) Kukafka, R., et al. “Redesigning Electronic Health Record Systems to Support Public Health.” Journal of Biomedical Informatics 40, no. 4 (August 2007): 398-409. Rommelmann, V., et al. “Cost and Results of Information Systems for Health and Poverty Indicators in the United Republic of Tanzania.” Bulletin of the World Health Organization 83, no. 8 (August 2005): 561-640. (PDF)
10	BioPharmaceuticals	BIO Ventures for Global Health (BVGH). “Closing the Global Health Innovation Gap: A Role for the Biotechnology Industry in Drug Discovery for Neglected Diseases.” 2007. ———. “Tuberculosis Vaccines: The Case for Investment.” October 2006. (PDF - 1.4 MB) Ginsberg, A. M., and M. Spigelman. “Challenges in Tuberculosis Drug Research and Development.” Nature Medicine 13, no. 3 (March 2007): 290-294. Nwaka, S., and A. Hudson. “Innovative Lead Discovery Strategies for Tropical Diseases.” Nature Reviews Drug Discovery 5 (November 2006): 941-955. Boston Consulting Group. “Market Assessment for Malaria Vaccines.” (PDF - 2MB) January 2005.
11	Vaccines development	Foster, S., et al. “Ensuring Supplies of Appropriate Drugs and Vaccines.” Chapter 72 in Disease Control Priorities in Developing Countries (DCP). 2nd ed. World Bank, 2006. Batson, A., et al. “Chapter 26: Innovative Financing Mechanisms to Accelerate the Introduction of HPV Vaccines in Developing Countries.” Vaccine 24, Supplement 3 (2006): S3/219-S3/225. Munira and Fritzen. “What Influences Government Adoption of Vaccines in Developing Countries? A Policy Process Analysis.” Social Science - Medicine 2007. Herling, P. “Patent Sense.” Nature 449 (September 13, 2007): 174-175. Hotez, P. J., and M. T. Ferris. “The Antipoverty Vaccines.” Vaccine 24 (2006): 5787-5799. Berndt, E. R., et al. “Advance Market Commitments for Vaccines Against Neglected Diseases: Estimating Costs and Effectiveness.” Health Economics 16 (2007): 491-511. International AIDS Vaccine Initiative (IAVI). “Forecasting Demand for Preventive HIV Vaccines in India.” ( PDF) Policy Research Working Paper #13, June 2007.
12	Technology innovation	Center for Integration of Medicine and Innovative Technology (CIMIT) Global Health Initiative. Famous folks Friedrich, M. J. “Jeffrey Sachs, PhD: Ending Extreme Poverty, Improving the Human Condition.” JAMA 298, no. 16 (October 24/31, 2007): 1849-1851. Sachs, P., et al. “The African Millennium Villages.” PNAS 104, no. 43 (October 23, 2007): 16775-16780. Furin, J. J., et al. “Expanding Global HIV Treatment: Case Studies from the Field.” Ann N Y Acad Sci 1136 (2008): 12-20. Prahalad, C. K. “The Innovation Sandbox.” strategy+business (Booz & Co.), Autumn 2006. Public private partnerships Vian, T., et al. “Public-Private Partnerships to Build Human Capacity in Low Income Countries: Findings from the Pfizer Program.” Human Resources for Health 5, no. 8 (2007). Widdus, R. “Public-Private Partnerships for Health: Their Main Targets, Their Diversity, and Their Future Directions.” Bulletin of the World Health Organization 79, no. 8 (2001): 713-20. Mullan, F. “The Metrics of the Physician Brain Drain.” NEJM 353, no. 17 (October 27, 2005): 1810-1818. Health systems Wang, H., T. Xu, and J. Xu. “Factors Contributing to High Costs and Inequality in China’s Health Care System.” JAMA 298, no. 16 (October 24/31, 2007): 1928-1930. Water and sanitation Hutton, G., and J. Bartram. “Global Costs of Attaining the Millennium Development Goal for Water Supply and Sanitation.” Bulletin of the World Health Organization 86, no. 1 (January 2008): 13-19.
13	Venture philanthropy	Pronyk, P. M., J. R. Hargreaves, and J. Morduch. “Microfinance Programs and Better Health Prospects for Sub-Saharan Africa.” JAMA 298, no. 16 (Oct 24/31, 2007): 1925-1927. Prahalad, C. K. Excerpt from The Fortune at the Bottom of the Pyramid. (PDF) FAQ on social entrepreneurship from David Bornstein’s blog
14	Final overview and lessons learned
15	Final projects and presentations