Statistical Physics in Biology

Protein Folding 2: Evolved (Designed) Foldable Proteins

1. Biomolecular Forces
   • van der Waals interactions
   • Hydrogen bonds
   • Hydrophobic effect
   • Hydrophobic collapse
2. Protein Folding Problem(s)
   • Anfinsen experiment
   • Thermodynamic hypothesis
   • Levinthal paradox
3. Thermodynamics of folding
   • Cooperativity
4. Energy Gap