Looking for something specific in this course? The Resource Index compiles links to most course resources in a single page.
Module I: Basic Biochemistry
Lecture Topics
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Readings
- Chapter 1: Introduction to the Chemistry of Life
- Chapter 2: Water
- Chapter 4: Amino Acids
Lecture Notes
Problem Set & Solutions
Problem Solving Video: Problem Set 1, Problem 1: Sizes and Equilibria
This problem is designed to give students a better intuition about the scales and dimensions of the cellular environment. Dr. Fedeles uses the examples of eukaryotic red blood cells and prokaryotic staph aureus cells to explore these ideas.
Lecture Topics
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Readings
- Chapter 5: Proteins: Primary Structure
- Polypeptide Diversity
- Protein Purification and Analysis
- Protein Sequencing
- Chapter 6: Proteins: Three-Dimensional Structure
- Secondary Structure
- Tertiary Structure
- Quaternary Structure and Symmetry
- Protein Stability
- Protein Folding
- Chapter 7: Protein Function: Myoglobin and Hemoglobin, Muscle Contraction, and Antibodies
- Oxygen Binding to Myoglobin and Hemoglobin
Lecture Notes
Lecture Topics
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Readings
- Chapter 11: Enzymatic Catalysis
- General Properties of Enzyme
- Activation Energy and the Reaction Coordinate
- Catalytic Mechanisms
- Serine Proteases
Lecture Video: Enzymes and Catalysis
In this classroom lecture, Professor Stubbe focuses on enzymes as catalysts. She describes the theory and mechanics of catalysis and explains why enzymes are so important.
Lecture Notes
Problem Set & Solutions
Problem Solving Video: Problem Set 2, Problem 1: Primary Structure
This problem is about elucidating the primary structure of a protein. Dr. Fedeles uses traditional chemical methods to analyze the data and produce a big picture result. This is the very same process by which discoveries are made.
Lecture Topics
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Readings
- Chapter 12: Enzyme Kinetics, Inhibition, and Control
- Reaction Kinetics
- Enzyme Inhibition
- Control of Enzyme Activity
Lecture Notes
Problem Set & Solutions
Problem Solving Video: Problem Set 3, Question 2: Proteases: Mechanisms of inhibition
In this problem, Dr. Fedeles explores the mechanisms of inhibition enzymes, in this case, proteases. In particular, it deals with possible mechanisms of inhibition of Interleukin Converting Enzyme (ICE).
Lecture Topics
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Readings
- Chapter 14: Introduction to Metabolism
- Oxidation Reduction Reaction
- Experimental Approaches to the Study of Metabolism
Lecture Notes
Lecture Video: Carbonyl Chemistry
One of the most diverse chemical groups is the carbonyl – a carbon atom double-bonded to an oxygen atom. This video summarizes some of the most important carbonyl reactions discussed in this course.
Problem Set & Solutions
Problem Solving Video: Problem Set 4, Problem 2: The Mechanism of HMG-CoA Synthase
In this video, Dr. Fedeles discusses in detail the mechanism of HMG-CoA Synthase. HMG-CoA is a key enzyme in central metabolism responsible for making the 5-carbon building blocks from which all sterols, such as cholesterol and steroid hormones, are made.
Lecture Topics
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Readings
- Chapter 14: Introduction to Metabolism
- High Energy Compounds
Lecture Notes
Lecture Topics
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Readings
- Chapter 18: Electron Transport and Oxidative Phosphorylation
- Electron Transport
Lecture Notes
Problem Set & Solutions
Problem Solving Video: Problem Set 5, Problem 5: How Mannose, an Isomer of Glucose, Enters Glycolysis
This problem is about sugar biochemistry. Specifically, it deals with how mannose, an isomer of glucose, gets to enter metabolism by being converted into fructose-6-phoshate.
Course Info
Departments
As Taught In
Fall
2013
Level
Topics
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