Biological Chemistry I

Session 10: Respiration: TCA Cycle

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Lecture Topics

Detailed Analysis of the TCA Cycle Prochirality and Label Tracking Anapleurotic Pathways

Readings

• Chapter 17: Citric Acid Cycle
  • Synthesis of Acetyl-Coenzyme A
  • Enzymes of the Citric Acid Cycle
  • Regulation of the Citric Acid Cycle
  • Reactions Related to the Citric Acid Cycle

Lecture Video: Respiration: TCA Cycle

This video focuses on the TCA Cycle, also called the Krebs Cycle or Citric Acid Cycle. Professor Essigmann reviews in detail the enzymes and regulation of the TCA Cycle as well as intersecting pathways (e.g., anapleurotic reactions).

• Storyboards 7–9, 11 (PDF)

Problem Set & Solutions

• Problem Set 7 (PDF)
• Solutions to Problem Set 7 (PDF)

Problem Solving Video: Problem Set 7, Problem 1: Tracing Labels through Pathways

This problem deals with tracking a labeled atom through various metabolic pathways. This process is one of the established ways to test whether the mechanism we propose for these pathways is, in fact, consistent with what we observe inside the cells.

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