Biological Chemistry I

Session 4: Enzyme Kinetics and Enzyme Inhibition

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Lecture Topics

Enzymatic Reactions and Chemically Catalyzed Reactions vs. Uncatalyzed Chemical Reactions Inhibitors of Enzyme Reactions

Readings

• Chapter 12: Enzyme Kinetics, Inhibition, and Control
  • Reaction Kinetics
  • Enzyme Inhibition
  • Control of Enzyme Activity

Lecture Notes

• Enzymes Kinetics and Enzyme Inhibition (PDF)

Problem Set & Solutions

• Problem Set 3 (PDF)
• Solutions to Problem Set 3 (PDF)

Problem Solving Video: Problem Set 3, Question 2: Proteases: Mechanisms of inhibition

In this problem, Dr. Fedeles explores the mechanisms of inhibition enzymes, in this case, proteases. In particular, it deals with possible mechanisms of inhibition of Interleukin Converting Enzyme (ICE).

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