5.07SC | Fall 2013 | Undergraduate

Biological Chemistry I

Module II: Production of Energy in the Cell

Session 12: Respiration: Electron Transport and Oxidative Phosphorylation

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Lecture Topics

  • The Role of Electron Transport to Generate Proton Gradients
  • Mobile e Carriers
  • Integral Membrane Proteins as Electron Conduits
  • Thermodynamics of ATP Synthesis


  • Chapter 18: Electron Transport and Oxidative Phosphorylation
    • The Mitochondrion
    • Oxidative Phosphorylation
    • Control of Oxidative Metabolism

Lecture Video: PLP Chemistry

Pyridoxal Phosphate (PLP), an essential metabolism cofactor derived from Vitamin B6, is involved in many chemical transformations. This video summarizes the most important ones and shows how to write the curved arrow mechanisms for these transformations.

Lecture Video: Respiration: Electron Transport and Oxidative Phosphorylation

In this video, Professor Essigmann returns to the topic of respiration. He details how to convert the electron transport potential of NADH and FADH2 into the phosphate transfer potential of ATP.

Problem Set & Solutions

Problem Solving Video: Problem Set 8, Problem 2: Bioenergetics of the Electron Transport Chain

In this problem, Dr. Fedeles focuses on the electron transport chain. This fundamental redox process converts the chemical energy of the covalent bonds into an electrochemical gradient.

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Course Info

As Taught In
Fall 2013
Learning Resource Types
Lecture Videos
Other Video
Problem Sets with Solutions
Lecture Notes
Instructor Insights