Biological Chemistry I

Resource Index

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This resource index gives users access to most of the course resources in a single location.

This Course at MIT

MEET THE EDUCATORS VIDEOS	INSTRUCTOR INSIGHTS VIDEOS
How Can You Not Think Enzymes are Cool? Research Focus: Ribonucleotide Reductases (RNRs) Becoming a Toxicologist Research Focus: Genetic Change	Focusing on the Morphological Unit of Life Using a Vitamin Bottle as a Teaching Tool Teaching Central Pathways to Help Students Understand Metabolism Why Students Should Memorize Amino Acid Side Chains Motivating Students to Study Metabolic Biochemistry with Oncology Applications Advice for Next Teaching Generation: Focus Curricula on the Microbial World

Lexicon

VIDEOS	RELATED FILES
Lexicon of Biochemical Reactions: Introduction	Lexicon of Biochemical Reactions (PDF - 1.2MB) Metabolic Pathways Chart
Lexicon of Biochemical Reactions: Cofactors Formed from Vitamin B12
Lexicon of Biochemical Reactions: Vitamin B6 / PLP
Lexicon of Biochemical Reactions: Redox Cofactors

Module I: Basic Biochemistry

TOPICS	LECTURE NOTES	LECTURE VIDEOS	PROBLEM SETS AND SOLUTIONS	PROBLEM SOLVING VIDEOS
What is Biochemistry?	What is Biochemistry? (PDF)	no video	Problem Set 1 (PDF) Solutions to Problem Set 1 (PDF)	Problem Set 1, Problem 1: Sizes and Equilibria
Protein Structure and Function	Introduction to Protein Structure and Function (PDF - 1.2MB) Protein Structure and Function Continued (PDF)	no video
Enzymes and Catalysis	Enzymes and Catalysis (PDF)	Lecture 5: Enzymes and Catalysis	Problem Set 2 (PDF) Solutions to Problem Set 2 (PDF)	Problem Set 2, Problem 1: Primary Structure
Enzyme Kinetics and Enzyme Inhibition	Enzymes Kinetics and Enzyme Inhibition (PDF)	no video	Problem Set 3 (PDF) Solutions to Problem Set 3 (PDF)	Problem Set 3, Question 2: Proteases: Mechanisms of Inhibition
Biochemical Transformations I	Biochemical Transformations I (PDF)	Carbonyl Chemistry	Problem Set 4 (PDF) Solutions to Problem Set 4 (PDF)	Problem Set 4, Problem 2: The Mechanism of HMG-CoA Synthase
Biochemical Transformations II	Biochemical Transformations II (PDF)	no video
Biochemical Transformations III	Biochemical Transformations III (PDF)	no video	Problem Set 5 (PDF) Solutions to Problem Set 5 (PDF)	Problem Set 5, Problem 5: How Mannose, an Isomer of Glucose, Enters Glycolysis

Module II: Production of Energy in the Cell

TOPICS	LECTURE NOTES	LECTURE VIDEOS	PROBLEM SETS AND SOLUTIONS	PROBLEM SOLVING VIDEOS
Introduction to Sugar Chemistry and Carbohydrate Catabolism	Introduction to Sugar Chemistry (PDF) Overview of Glycolysis (PDF - 1.1MB) Storyboard 1 (PDF) Metabolic Chart (PDF) Abbreviations List (PDF)	ses 8: Intro to Sugar Chemistry and Carbohydrate Catabolism	Problem Set 6 (PDF) Solutions to Problem Set 6 (PDF)	Problem Set 6, Problem 2: Mechanism of Phosphoglycerate Mutase
Glycolysis and Early Stages of Respiration	Endings to Glycolysis (PDF - 1.2MB) Storyboards 2-7 (PDF) Pyruvate Dehydrogenase Slides (PDF)	ses 9: Glycolysis and Early Stages of Respiration
Respiration: TCA Cycle	Storyboards 7-9, 11 (PDF)	ses 10: Respiration: TCA Cycle	Problem Set 7 (PDF) Solutions to Problem Set 7 (PDF)	Problem Set 7, Problem 1: Tracing Labels through Pathways
Maintenance of Redox Neutrality	Storyboard 10 (PDF)	Ses 11: Maintenance of Redox Neutrality
Respiration: Electron Transport and Oxidative Phosphorylation	Storyboards 12-13 (PDF)	PLP (Pyridoxal Phosphate) Chemistry Ses 12: Respiration: ETOP	Problem Set 8 (PDF) Solutions to Problem Set 8 (PDF)	Problem Set 8, Question 2: Bioenergetics of the Electron Transport Chain
Respiration: Proton Pumps and ATP Synthesis	Storyboards 14-16 (PDF)	Ses 13: Respiration: Proton Pumps and ATP Synthesis
Lipid Catabolism: Fatty Acid Beta-Oxidation	Storyboards 17-18 (PDF)	Ses 14: Lipid Catabolism: Fatty Acid Beta-Oxidation
Special Cases in Fatty Acid Metabolism	Storyboards 19-22 (PDF)	Ses 15: Special Cases in Fatty Acid Metabolism	Problem Set 9 (PDF) Solutions to Problem Set 9 (PDF)	Problem Set 9, Problem 1: Catabolism of Triacylglycerols
Ketogenesis, Diabetes and Starvation	Storyboards 23-24 (PDF)	Session 16: Ketogenesis, Diabetes and Starvation

Module III: Using Energy to Make Macromolecules

TOPICS	LECTURE NOTES	LECTURE VIDEOS	PROBLEM SETS AND SOLUTIONS	PROBLEM SOLVING VIDEOS
Fatty Acid and Lipid Biosynthesis	Storyboards 25-28 (PDF)	Ses 17: Fatty Acid and Lipid Biosynthesis
Carbohydrate Biosynthesis I: Glycogen Synthesis	Storyboards 29-30 (PDF)	Session 18: Carbohydrate Biosynthesis I: Glycogen Synthesis
Carbohydrate Biosynthesis II: Gluconeogenesis	Storyboards 31-32 (PDF)	ses19: Carbohydrate Biosynthesis II: Gluconeogenesis	Problem Set 10 (PDF) Solutions to Problem Set 10 (PDF)	Problem Set 10, Problem 3: Gluconeogenesis
Carbohydrate Biosynthesis III: Pentose Phosphate Pathway	Storyboards 33-35 (PDF)	ses20: Carbohydrate Biosynthesis III: Pentose Phosphate Pathway
Regulation of Metabolism	Storyboards 36-39 (PDF)	ses21: Regulation of Metabolism

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