5.111SC | Fall 2014 | Undergraduate

Principles of Chemical Science

Unit III: Thermodynamics & Chemical Equilibrium

« Previous | Next »

Using the description of the atom and of atomic properties from Unit I and using knowledge about bonding and molecular structure from Unit II, in Unit III we investigate how, why, and when molecules react with each other. Will they or Won’t they? That is the question that thermodynamics answers for us. Viewers of this unit will be introduced to Gibbs free energy, enthalpy and entropy, and will learn the key to spontaneity. Most reactions are reversible and thus understanding chemical equilibrium is of the utmost importance. What will the ratio of products to reactants be at equilibrium? How can this ratio be manipulated by factors such as temperature or pressure? By the end of this unit, viewers will have the tools needed to work even the most challenging of chemical equilibrium problems, i.e. those that involve acids and bases. Viewers will be able to design a strategy for shifting the equilibrium of a reaction to make a desired product. They will have a working knowledge of thermodynamics and equilibrium such that they can apply that knowledge to other disciplines, and be ready to help solve real world problems like climate change and the development of new medical therapies.

Image excerpted from Lecture 15 Notes Lecture 15: Thermodynamics: Bond and Reaction Enthalpies

Image excerpted from Lecture 16 Notes Lecture 16: Thermodynamics: Gibbs Free Energy and Entropy

Image excerpted from Lecture 17 Notes Lecture 17: Thermodynamics: Now What Happens When You Heat It Up?

Image excerpted from Lecture 18 Notes Lecture 18: Introduction to Chemical Equilibrium

Image excerpted from Lecture 19 Notes Lecture 19: Chemical Equilibrium: Le Châtelier’s Principle

Image excerpted from Lecture 20 Notes Lecture 20: Solubility and Acid-Base Equilibrium

Image excerpted from Lecture 21 Notes Lecture 21: Acid-Base Equilibrium: Is MIT Water Safe to Drink?

Image excerpted from Lecture 22 Notes Lecture 22: Acid-Base Equilibrium: Salt Solutions and Buffers

Image excerpted from Lecture 23 Notes Lecture 23: Acid-Base Titrations Part I

Image excerpted from Lecture 24 Notes Lecture 24: Acid-Base Titrations Part II

Looking for something specific in this course? The Resource Index compiles links to most course resources in a single page.

« Previous | Next »

« Previous | Next »

Topics

Image excerpted from Lecture 15 Notes 

  1. Thermodynamics
    1. Bond Energy / Bond Enthalpy (∆HB)
    2. Enthalpies of Reaction (∆Hr)
    3. Methods to Calculate ∆Hr

Lecture Video

Thermodynamics is key to understanding the reactivity of molecules and compounds. In this first of three lectures on thermodynamics, viewers are introduced to ∆H, and asked to consider how much heat it will take to break one type of molecular bond versus another. Viewers are also asked whether a particular chemical reaction will release heat or absorb heat.

Lecture Notes

Notes for Lecture 15 (PDF)

Clicker Questions

Lecture 15 Clicker Questions (PDF)

Textbook Reading

TOPICS 5th EDITION 4th EDITION
The Enthalpy of Chemical Change Sections 7.13, 7.15, 7.16, 7.17, 7.18, and 7.20 Sections 6.13, 6.15, 6.16, 6.17, 6.18, and 6.20

Problems and Solutions

Problems for Lecture 15 (PDF)

Solutions for Lecture 15 (PDF)

Acknowledgement

Excerpt of “Photosynthesis” by They Might Be Giants, courtesy of Idlewild / Disney Sound, used with permission. From Here Comes Science, 2009

« Previous | Next »

« Previous | Next »

Topics

Image excerpted from Lecture 16 Notes 

  1. Thermodynamics
    1. Spontaneous Change and Free Energy
    2. Entropy
    3. Free Energy of Formation

Lecture Video

If you mix two compounds together will they react spontaneously? How do you know? Find out the key to spontaneity in this lecture. Also, what does Robert Frost’s poetry have to do with entropy, and how can you prepare toothpaste for an elephant? Find out.

Lecture Notes

Notes for Lecture 16 (PDF)

Clicker Questions

Lecture 16 Clicker Questions (PDF)

Textbook Reading

TOPICS 5th EDITION 4th EDITION
Spontaneous Change Section 8.1 Section 7.1
Entropy Sections 8.2 and 8.8 Sections 7.2 and 7.8
Gibbs Free Energy Sections 8.12, 8.13, and 8.15 7.12, 7.13, and 7.15

Problems and Solutions

Problems for Lecture 16 (PDF)

Solutions for Lecture 16 (PDF)

« Previous | Next »

« Previous | Next »

Topics

Image excerpted from Lecture 17 Notes 

  1. Thermodynamics
    1. Effect of Temperature on Spontaneity
    2. Thermodynamics in Biological Systems
      1. Hydrogen-bonding
      2. ATP-coupled Reactions

Lecture Video

Chemistry is part of everyday life whether we realize it or not. In this lecture, we use thermodynamics to explain some basic observations made when cooking. Chemistry is also essential within living organisms, and we hear from researcher Lourdes Aleman about the importance of weak interactions known as hydrogen bonds.

Lecture Notes

Notes for Lecture 17 (PDF)

Clicker Questions

Lecture 17 Clicker Questions (PDF)

Textbook Reading

TOPICS 5th EDITION 4th EDITION
Gibbs Free-Energy Changes in Biological Systems Section 8.16 Section 7.16

Treating Diseases By Using RNAi Technology

RNA interference (RNAi) is a process in which small pieces of silencing RNA (siRNA) bind to cellular RNA, thereby shutting down the production of the encoded protein. Lourdes Alemán discusses how understanding hydrogen bonding and bond strengths is essential to her research on RNAi, and how scientists hope to apply RNAi technology in designing treatments for a wide variety of diseases.

Lourdes Alemán’s Personal Story

Lourdes Alemán, a Cuban-American, shares her greatest source of inspiration throughout her journey to becoming a scientist, a story of her father’s remarkable perseverance in the face of overwhelming adversity.

Problems and Solutions

Problems for Lecture 17 (PDF)

Solutions for Lecture 17 (PDF)

« Previous | Next »

« Previous | Next »

Topics

Image excerpted from Lecture 18 Notes 

  1. Chemical Equilibrium
    1. Nature of Chemical Equilibrium
    2. Meaning of the Chemical Equilibrium Constant K
    3. External Effects on K (Le Châtlier’s Principle)

Lecture Video

Reactions reach chemical equilibrium when the rate of the forward reaction equals the rate of the reverse reaction. In this lecture, we discuss the nature of chemical equilibrium and of the chemical equilibrium constant. We start to consider how external factors can “push” the equilibrium in one direction or the other. Physicist and Chemist Nozomi Ando provides an example of why chemical equilibrium is important in living organisms.

Lecture Notes

Notes for Lecture 18 (PDF)

Clicker Questions

Lecture 18 Clicker Questions (PDF)

Textbook Reading

TOPICS 5th EDITION 4th EDITION
Chemical Equilibrium Sections 10.1–10.5, and 10.9 Sections 9.1–9.4

Understanding Chemotherapeutic Drug Targets

Nozomi Ando conducts research on a protein that is essential for DNA synthesis, repair, and replication. She explains how this protein is in equilibrium between an active and an inactive form, and how discovering strategies to lock the protein in the inactive conformation could lead to treatments for cancer and/or could be used in the creation of new antibiotics.

Nozomi Ando’s Personal Story

Nozomi Ando, a self-described artist and comic book lover, describes how her training to become a scientist was akin to that of a ninja. Like a ninja apprenticeship, expert scientists have worked with her at every stage of her career to show her the way of the scientist.

Problems and Solutions

Problems for Lecture 18 (PDF)

Solutions for Lecture 18 (PDF)

« Previous | Next »

« Previous | Next »

Topics

Image excerpted from Lecture 19 Notes 

  1. Chemical Equilibrium
    1. External Effects on K (Le Châtlier’s Principle) (continued)
    2. Temperature Dependence of K
    3. Applications of Le Châtlier’s Principle
  2. Significant Figure Rules for Logs

Lecture Video

A system in equilibrium that is subjected to a stress tends to respond in a way that minimizes that stress. In this lecture, viewers will learn about chemical reactions but will also learn some important life lessons.

Lecture Notes

Notes for Lecture 19 (PDF)

Clicker Questions

Lecture 19 Clicker Questions (PDF)

Textbook Reading

TOPICS 5th EDITION 4th EDITION
The Response of Equilibria to Changes in Conditions Sections 10.9–10.13 Sections 9.4–9.5

Problems and Solutions

Problems for Lecture 19 (PDF)

Solutions for Lecture 19 (PDF)

Acknowledgement

Chemists Know” courtesy of Rachel Martin, Eric Potoma, and Gianmarc Grazioli of the UC Irvine Department of Chemistry. Used with permission.

« Previous | Next »

« Previous | Next »

Topics

Image excerpted from Lecture 20 Notes

 

  1. Solutions and Solubility
  2. Classification of Acids and Bases

Lecture Video

If you have ever tried to get a stain out of a favorite garment or struggled to clean your bathtub after a long period of neglect, this lecture is for you. Understanding solubility is important whether you want to design a new cancer drug, want to save the planet by removing greenhouse gases from the environment like Chemist Hector Hernandez, or if you simply want to get your apartment ready for a visit from your parents.

Lecture Notes

Notes for Lecture 20 (PDF)

Clicker Questions

Lecture 20 Clicker Questions (PDF)

Textbook Reading

TOPICS 5th EDITION 4th EDITION
Solubility Sections 9.8–9.13 Sections 8.8–8.13
The Nature of Acids and Bases Sections 11.1–11.2, and 11.4–11.6 Sections 10.1–10.2, and 10.4–10.6

Harnessing Microbes For Carbon Dioxide Sequestration

Hector Hernandez describes how Le Chatelier’s principle and the effects of pressure on solubility relate to his research on harnessing microbes to remove carbon dioxide from the environment. Hector envisions that his research could someday be used to decrease greenhouse gas emissions from power plants.

Hector Hernandez’s Personal Story

Hector Hernandez initially worked in construction, but at age 29, he realized he wanted to use his mind instead of his back in his career. With the help of a key-mentor at a community college, he started studying chemistry, a subject that allowed him to apply his mechanical training and introduced him to colleagues who have become like family.

Problems and Solutions

Problems for Lecture 20 (PDF)

Solutions for Lecture 20 (PDF)

« Previous | Next »

« Previous | Next »

Topics

Image excerpted from Lecture 21 Notes 

  1. Definitions and Relationships between pKw, pH, and pOH
  2. Strengths of Acids and Bases
  3. Equilibrium Acid-Base Problems (Weak Acids and Weak Bases)

Lecture Video

If the pH of water was 2, would you drink it? What about if the water had a pH of 11? The lecture introduces the concept of pH and we measure the pH of various common solutions.

Lecture Notes

Notes for Lecture 21 (PDF - 1.2MB)

Clicker Questions

Lecture 21 Clicker Questions (PDF - 1.1MB)

Textbook Reading

TOPICS 5th EDITION 4th EDITION
Weak Acids and Bases Sections 11.7–11.9 Sections 10.7–10.9
The pH of Solutions of Weak Acids and Bases Sections 11.11–11.13 Sections 10.11–10.13

Problems and Solutions

Problems for Lecture 21 (PDF)

Solutions for Lecture 21 (PDF)

« Previous | Next »

« Previous | Next »

Topics

Image excerpted from Lecture 22 Notes 

  1. pH of Salt Solutions
  2. Buffers!

Lecture Video

A buffer helps to maintain a constant pH. Our blood has a natural buffering system to ensure that the pH of our blood stays within a narrow window and that we stay health. In this lecture, we consider how to design a buffer. We also discuss how one can predict the pH of a salt solution. At dinner if you put table salt in your water glass, how would the pH of the water change? or would it change?

Lecture Notes

Notes for Lecture 22 (PDF)

Clicker Questions

Lecture 22 Clicker Questions (PDF - 1.1MB)

Textbook Reading

TOPICS 5th EDITION 4th EDITION
Autoprotolysis and pH Sections 11.13 and 11.18–11.19 Sections 10.13 and 10.18–10.19
Mixed Solutions and Buffers Sections 12.1–12.3 Sections 11.1–11.3

Problems and Solutions

Problems for Lecture 22 (PDF)

Solutions for Lecture 22 (PDF)

« Previous | Next »

« Previous | Next »

Topics

Image excerpted from Lecture 23 Notes 

  1. Acid-Base Titrations
    1. Titration of Strong Acids and Strong Bases
    2. Titration of Weak Acids / Strong Bases & Strong Acids/Weak Bases

Lecture Video

A common chemistry laboratory experiment involves titrating a strong base into a weak acid, drop by drop, until a color change of an indicator dye tells the student that the equivalence point has been reached. By determining the volume of strong based needed to reach the equivalence point, the molecular weight and/or pKa of the weak acid can be determined. In this lecture, we start to work through the calculations underlying acid-base titrations.

Lecture Notes

Notes for Lecture 23 (PDF)

Clicker Questions

Lecture 23 Clicker Questions (PDF)

Textbook Reading

TOPICS 5th EDITION 4th EDITION
Titrations Sections 12.4–12.6 Sections 11.4–11.6

Problems and Solutions

Problems for Lecture 23 (PDF)

Solutions for Lecture 23 (PDF)

« Previous | Next »

« Previous | Next »

Topics

Image excerpted from Lecture 24 Notes 

  1. Acid-Base Titrations
    1. Titration of Weak Acid with Strong Base (continued)

Lecture Video

We finish the topic of acid-base titrations and consider why pKa is so important. Chemist Samuel Thompson talks about a problem he encountered in his undergraduate research that had to do with the pKa of a molecular probe. Learn what the problem was and how he solved it.

Lecture Notes

Notes for Lecture 24 (PDF)

Clicker Questions

Lecture 24 Clicker Questions (PDF)

Textbook Reading

TOPICS 5th EDITION 4th EDITION
Redox Reactions Section K Section K
Titrations Sections 12.4–12.6 11.4–11.6
Representing Redox Reactions 13.1–13.2 13.1–13.2

Designing Probes To Image Proteins Inside Living Cells

Samuel Thompson discusses his research on designing new tools to track the movement of proteins within cells. He explains how understanding the relationship between pKa and pH was critical for the design of a new sensor, which he hopes can be used to image proteins in diseased cells.

Samuel Thompson’s Personal Story

Samuel Thompson brings a sense of play to his science research that he traces back to his love of the performing arts and his early exposure to science as a child. He also relates that his identity as a gay-man from a conservative Southern town helped shape him into a scientist.

Problems and Solutions

Problems for Lecture 24 (PDF)

Solutions for Lecture 24 (PDF)

« Previous | Next »

Course Info

Departments
As Taught In
Fall 2014
Learning Resource Types
Lecture Videos
Lecture Notes
Problem Sets with Solutions
Exams with Solutions
Other Video
Instructor Insights